Technology Process of 4-<4-(phenylethynyl)phenylethynyl>-2,6-bispyridine
There total 3 articles about 4-<4-(phenylethynyl)phenylethynyl>-2,6-bispyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 2 steps
1: 1.) bis(triphenylphosphine)palladium(II) chloride, copper(I) iodide, triethylamine, 2.) sodium hydroxide / 1.) room temperature, 2 h, 2.) toluene reflux, 4 h
2: 1.) bis(triphenylphosphine)palladium(II) chloride, copper(I) iodide, triethylamine, 2.) trufluoroacetic acid / 1.) tetrahydrofuran, 50 deg C, 24 h, 2.) room temperature, 1.5 h
With
sodium hydroxide; copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; triethylamine; trifluoroacetic acid;
- Guidance literature:
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Multi-step reaction with 3 steps
1: 1.) sodium nitrite, H2SO4, 2.) potassium iodide, H2SO4 / 1.) water, 5 deg C, 1 h, 2.) 5 deg C, 1 h
2: 1.) bis(triphenylphosphine)palladium(II) chloride, copper(I) iodide, triethylamine, 2.) sodium hydroxide / 1.) room temperature, 2 h, 2.) toluene reflux, 4 h
3: 1.) bis(triphenylphosphine)palladium(II) chloride, copper(I) iodide, triethylamine, 2.) trufluoroacetic acid / 1.) tetrahydrofuran, 50 deg C, 24 h, 2.) room temperature, 1.5 h
With
sodium hydroxide; copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; sulfuric acid; triethylamine; trifluoroacetic acid; potassium iodide; sodium nitrite;
- Guidance literature:
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With
copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; triethylamine; trifluoroacetic acid;
Yield given. Multistep reaction;
1.) tetrahydrofuran, 50 deg C, 24 h, 2.) room temperature, 1.5 h;
