4-((1R,3S)-2-Benzyl-3-carbamoyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2,2-bis-phenylsulfanyl-butyric acid methyl ester

Base Information

• Chemical Name: 4-((1R,3S)-2-Benzyl-3-carbamoyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2,2-bis-phenylsulfanyl-butyric acid methyl ester
• CAS No.: 89209-40-5
• Molecular Formula: C₃₆H₃₅N₃O₃S₂
• Molecular Weight: 621.824
• Mol file: 89209-40-5.mol

Synonyms:

Chemical Property of 4-((1R,3S)-2-Benzyl-3-carbamoyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2,2-bis-phenylsulfanyl-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((1R,3S)-2-Benzyl-3-carbamoyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2,2-bis-phenylsulfanyl-butyric acid methyl ester

There total 1 articles about 4-((1R,3S)-2-Benzyl-3-carbamoyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2,2-bis-phenylsulfanyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diphenylthio-2,2' formyl-4 butyrate de methyle (84406-10-0) + L-Nb-benzyltryptophanamide → 4-((1R,3S)-2-Benzyl-3-carbamoyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2,2-bis-phenylsulfanyl-butyric acid methyl ester (89209-40-5)

Guidance literature:

With trifluoroacetic acid; Yield given. Multistep reaction; 1) benzene, reflux, 2) CH₂Cl₂, r.t.;

DOI:10.1039/c39830001147

Reference yield:

4-((1R,3S)-2-Benzyl-3-carbamoyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2,2-bis-phenylsulfanyl-butyric acid methyl ester (89209-40-5) → 4-((1R,3S)-2-Benzyl-3-cyano-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2,2-bis-phenylsulfanyl-butyric acid methyl ester (89209-42-7)

Guidance literature:

With trifluoroacetic anhydride;

DOI:10.1039/c39830001147

Reference yield:

4-((1R,3S)-2-Benzyl-3-carbamoyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2,2-bis-phenylsulfanyl-butyric acid methyl ester (89209-40-5) → 4-((R)-2-Benzyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2,2-bis-phenylsulfanyl-butyric acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: (CF₃CO)2O

2: NaBH₄

With sodium tetrahydroborate; trifluoroacetic anhydride;

DOI:10.1039/c39830001147

upstream raw materials:

diphenylthio-2,2' formyl-4 butyrate de methyle

Downstream raw materials:

4-((1R,3S)-2-Benzyl-3-cyano-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2,2-bis-phenylsulfanyl-butyric acid methyl ester