Aziridine, 2-ethenyl-3-(2-phenylethyl)-, (2R,3R)-

Base Information

Chemical Name:Aziridine, 2-ethenyl-3-(2-phenylethyl)-, (2R,3R)-
CAS No.:203398-09-8
Molecular Formula:C12H15N
Molecular Weight:173.258
Hs Code.:

Synonyms:

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Chemical Property of Aziridine, 2-ethenyl-3-(2-phenylethyl)-, (2R,3R)-

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Technology Process of Aziridine, 2-ethenyl-3-(2-phenylethyl)-, (2R,3R)-

There total 4 articles about Aziridine, 2-ethenyl-3-(2-phenylethyl)-, (2R,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 203397-90-4
(3S,4R)-4-amino-1-phenylhex-5-en-3-ol

: 203398-09-8
(2R,3R)-2-phenethyl-3-vinylaziridine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 17h; Heating;
DOI:10.1021/jo0262053

Reference yield:

: 203397-83-5
(2S,3S)-2-phenethyl-3-vinyloxirane

: 203398-09-8
(2R,3R)-2-phenethyl-3-vinylaziridine

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / aq. NH₃ / 0.13 h / Heating

2: 80 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 17 h / Heating

With ammonium hydroxide; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 2: Mitsunobu reaction;
DOI:10.1021/jo0262053

Reference yield:

: 125303-61-9
[(2S,3S)-3-phenethyloxiran-2-yl]methanol

: 203398-09-8
(2R,3R)-2-phenethyl-3-vinylaziridine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 105 min, 2.) -78 deg C, 30 min; -78 deg C to r.t.

2: 1.) KHMDS / 1.) THF, toluene, r.t., 1 h, 2.) THF, -20 deg C to r.t., 40 min

3: 77 percent / NH₃, TsOH*H₂O / 96 h / 130 °C

4: 52 percent / PPh₃, DEAD / toluene / 18 h / Heating

With oxalyl dichloride; ammonia; potassium hexamethylsilazane; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; In toluene;