Pyrido[2,3-d]pyridazine, 8-chloro-5-(4-methylphenyl)-

Base Information

Chemical Name:Pyrido[2,3-d]pyridazine, 8-chloro-5-(4-methylphenyl)-
CAS No.:203728-97-6
Molecular Formula:C14H10ClN3
Molecular Weight:255.707
Hs Code.:
DSSTox Substance ID:DTXSID40440820
Wikidata:Q82257245

Synonyms:203728-97-6;SCHEMBL8549613;Pyrido[2,3-d]pyridazine, 8-chloro-5-(4-methylphenyl)-;DTXSID40440820

Suppliers and Price of Pyrido[2,3-d]pyridazine, 8-chloro-5-(4-methylphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Pyrido[2,3-d]pyridazine, 8-chloro-5-(4-methylphenyl)-

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:255.0563250
Heavy Atom Count:18
Complexity:278

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=NN=C(C3=C2C=CC=N3)Cl

Technology Process of Pyrido[2,3-d]pyridazine, 8-chloro-5-(4-methylphenyl)-

There total 7 articles about Pyrido[2,3-d]pyridazine, 8-chloro-5-(4-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 203728-96-5
5-(4-Methylphenyl)-7H-pyrido[2,3-d]pyridazin-8-one

: 203728-97-6
8-chloro-5-(4-methylphenyl)pyrido[2,3-d]pyridazine

Guidance literature:: With pyridine; trichlorophosphate; at 110 ℃; for 1h;
DOI:10.1080/00397919808004864

Reference yield:

: 211629-99-1
5-p-tolyl-pyrido[3,2-d][1,2]oxazin-8-one

: 203728-97-6
8-chloro-5-(4-methylphenyl)pyrido[2,3-d]pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate; acetic acid / Heating

2: 73 percent / phosphorus oxychloride; pyridine / 1 h / 110 °C

With pyridine; hydrazine hydrate; acetic acid; trichlorophosphate;
DOI:10.1080/00304940509354954

Reference yield:

: 108-88-3,15644-74-3,16713-13-6
toluene

: 203728-97-6
8-chloro-5-(4-methylphenyl)pyrido[2,3-d]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / AlCl₃ / 2 h / 80 °C

2: 80 percent / H₂NNH₂*H₂O / acetic acid / 2 h / Heating

3: 73 percent / POCl₃; pyridine / 1 h / 110 °C

With pyridine; aluminium trichloride; hydrazine hydrate; trichlorophosphate; In acetic acid; 1: Rearrangement / 2: Substitution / 3: Chlorination;
DOI:10.1080/00397919808004864