3-PHENYL-1-P-TOLYL-PROPYNONE

Base Information

• Chemical Name: 3-PHENYL-1-P-TOLYL-PROPYNONE
• CAS No.: 20442-65-3
• Molecular Formula: C16H12O
• Molecular Weight: 220.271
• Hs Code.: 2914399090
• Mol file: 20442-65-3.mol

Synonyms:1-(p-methylphenyl)-3-phenyl-2-propyn-1-one;1-(4-methylphenyl)-3-phenylprop-2-yn-1-ol;3-phenyl-1-(4-methylphenyl)-2-propyn-1-one;HMS1440A07;1-(4-methylphenyl)-3-phenyl-2-propyn-1-one;1-(4-methylphenyl)-3-phenylpropynone;Phenylethynyl p-tolyl ketone;3-phenyl-1-(4-methylphenyl)-2-propynone;

Chemical Property of 3-PHENYL-1-P-TOLYL-PROPYNONE

Chemical Property:

• Melting Point: 69-70 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 368.0±35.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 3.22940

Purity/Quality:

99% ^*data from raw suppliers

3-PHENYL-1-PARA-TOLYL-PROPYNONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-PHENYL-1-P-TOLYL-PROPYNONE

There total 75 articles about 3-PHENYL-1-P-TOLYL-PROPYNONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methyl-benzoyl chloride (874-60-2) + phenylacetylene (536-74-3) → 1-(4-methylphenyl)-3-phenylprop-2-yn-1-one (20442-65-3)

Guidance literature:

4-methyl-benzoyl chloride; With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

With copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

phenylacetylene; In tetrahydrofuran; at 20 ℃; for 6.25h; Inert atmosphere;

DOI:10.1016/j.tet.2015.04.070

Reference yield: 99.0%

4-methyl-benzoyl chloride (874-60-2) + potassium (2-phenylethynyl)trifluoroborate → 1-(4-methylphenyl)-3-phenylprop-2-yn-1-one (20442-65-3)

Guidance literature:

potassium (2-phenylethynyl)trifluoroborate; With boron trichloride; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere; Sonication;

4-methyl-benzoyl chloride; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol403370t

Reference yield: 96.0%

1-(4-methylphenyl)-3-phenylprop-2-yn-1-ol (59931-62-3) → 1-(4-methylphenyl)-3-phenylprop-2-yn-1-one (20442-65-3)

Guidance literature:

With tert.-butylhydroperoxide; In dichloromethane; at 40 ℃; for 2h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2015.01.177

upstream raw materials:

(phenylethynyl)sodium

4-methyl-benzoyl chloride

phenylacetylene

4-methylbenzoyl cyanide

Downstream raw materials:

ethyl 2-oxo-4-phenyl-6-(p-tolyl)-2H-pyran-3-carboxylate

(Z)-3-(4-Methoxy-phenylsulfanyl)-3-phenyl-1-p-tolyl-propenone

(Z)-3-(4-Chloro-phenylsulfanyl)-3-phenyl-1-p-tolyl-propenone

(3,3-difluoro-2-phenyl-cycloprop-1-enyl)-p-tolyl-methanone