5-(2-CHLORO-BENZYL)-THIAZOL-2-YLAMINE

Base Information

• Chemical Name: 5-(2-CHLORO-BENZYL)-THIAZOL-2-YLAMINE
• CAS No.: 207463-32-9
• Molecular Formula: C10H9ClN2S
• Molecular Weight: 224.714
• Hs Code.: 2934100090
• Mol file: 207463-32-9.mol

Synonyms:5-(2-chlorobenzyl)-1,3-thiazol-2-amine;5-(2-Chloro-benzyl)-thiazol-2-ylamine;5-(2-Chlorobenzyl)thiazol-2-amine;5-[(2-chlorophenyl)methyl]-1,3-thiazole-2-ylamine;

Chemical Property of 5-(2-CHLORO-BENZYL)-THIAZOL-2-YLAMINE

Chemical Property:

• PSA: 67.15000
• LogP: 3.55070

Purity/Quality:

98%min ^*data from raw suppliers

5-[(2-Chlorophenyl)methyl]-1,3-thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-CHLORO-BENZYL)-THIAZOL-2-YLAMINE

There total 6 articles about 5-(2-CHLORO-BENZYL)-THIAZOL-2-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

thiourea (17356-08-0) + 2-chloro-3-(2-chloro-phenyl)-propionaldehyde (207463-28-3) → 5-(2-chlorobenzyl)-2-thiazolamine (207463-32-9)

Guidance literature:

In ethanol; Heating;

Reference yield: 77.0%

tert-butyl-{5-[hydroxyl(2-chlorophenyl)methyl]thiazol-2-yl}carbamate → 5-(2-chlorobenzyl)-2-thiazolamine (207463-32-9)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2014.12.006

Reference yield:

o-chloroaniline (95-51-2) → 5-(2-chlorobenzyl)-2-thiazolamine (207463-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0 °C

1.2: 0.5 h / pH 6 - 7

1.3: 12 h

2.1: ethanol / 20 °C

With hydrogenchloride; sodium nitrite; In ethanol; water; 1.3: |Meerwein Arylation;

DOI:10.1016/j.bmcl.2021.128083

upstream raw materials:

thiourea

2-chloro-3-(2-chloro-phenyl)-propionaldehyde

2-chlorobenzenediazonium chloride

2-chloro-benzaldehyde

Downstream raw materials:

N-[5-(2-chloro-benzyl)-thiazol-2-yl]-2,2-diphenyl-acetamide

2-bromo-N-[5-(2-chloro-benzyl)-thiazol-2-yl]-butyramide

C₁₂H₁₀Cl₂N₂OS

2-bromo-N-[5-(2-chloro-benzyl)-thiazol-2-yl]-2-phenyl-acetamide

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