2-bromo-2'-methoxy-1,1'-Biphenyl

Base Information

• Chemical Name: 2-bromo-2'-methoxy-1,1'-Biphenyl
• CAS No.: 20837-12-1
• Molecular Formula: C13H11BrO
• Molecular Weight: 263.134
• Mol file: 20837-12-1.mol

Synonyms:2-bromo-2'-methoxybiphenyl;2'-bromo-2-methoxybiphenyl;2-bromo-2’-methoxybiphenyl;2′-bromo-2-methoxybiphenyl;2'-Bromo-2-methoxy-biphenyl;2-Bromo-2'-methoxy-1,1'-biphenyl;

Chemical Property of 2-bromo-2'-methoxy-1,1'-Biphenyl

Chemical Property:

• Melting Point: 58 °C
• Boiling Point: 101 °C (0.1 mmHg)
• PSA: 9.23000
• Density: 1.350±0.06 g/cm3(Predicted)
• LogP: 4.12470

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-2'-methoxy-1,1'-Biphenyl

There total 2 articles about 2-bromo-2'-methoxy-1,1'-Biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-Bromo-2-iodobenzene (583-55-1) + 2-Methoxyphenylboronic acid (5720-06-9) → 2-bromo-2’-methoxybiphenyl (20837-12-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 96h;

DOI:10.1021/ja3076555 DOI:10.1021/ja3076555

Reference yield: 73.0%

2-Methoxyphenylboronic acid (5720-06-9) + C6H4BrN2(1+)*C7H7O3S(1-) → 2-bromo-2’-methoxybiphenyl (20837-12-1)

Guidance literature:

With palladium diacetate; In water; at 20 ℃; for 96h; Inert atmosphere;

DOI:10.1055/s-0036-1588919

Reference yield: 80.0%

(2RP,4SC,5RC)-(+)-3,4-dimethyl-2,5-diphenyl-1,3,2-oxazaphospholidine borane + 2-bromo-2’-methoxybiphenyl (20837-12-1) → (SP)-[(1R,2S)-N-ephedrino](2′-methoxybiphenyl-2-yl)-(phenyl)phosphine P-borane

Guidance literature:

2-bromo-2’-methoxybiphenyl; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

(2R_P,4S_C,5R_C)-(+)-3,4-dimethyl-2,5-diphenyl-1,3,2-oxazaphospholidine borane; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo400565b

upstream raw materials:

1-Bromo-2-iodobenzene

2-Methoxyphenylboronic acid

Downstream raw materials:

bis(2'-methoxybiphenyl-2-yl)methanone

2-(2-hydroxyadamantan-2-yl)-2'-methoxybiphenyl

1-methoxy-5-phenyl-5H-dibenzophosphole 5-oxide

(2'-methoxybiphenyl-2-yl)phenylphosphine oxide