5-(benzyloxy)-1H-indole-2-carbohydrazide

Base Information

• Chemical Name: 5-(benzyloxy)-1H-indole-2-carbohydrazide
• CAS No.: 20948-66-7
• Molecular Formula: C16H15N3O2
• Molecular Weight: 281.30900
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00370750
• Wikidata: Q82157902
• Mol file: 20948-66-7.mol

Synonyms:5-(benzyloxy)-1H-indole-2-carbohydrazide;20948-66-7;5-phenylmethoxy-1H-indole-2-carbohydrazide;Maybridge1_005289;Oprea1_734919;HMS556I09;DTXSID00370750;MFCD02180366;AKOS004119705;CCG-249888;FT-0619686

Chemical Property of 5-(benzyloxy)-1H-indole-2-carbohydrazide

Chemical Property:

• Melting Point: 219-221oC
• PSA: 80.14000
• Density: 1.313g/cm3
• LogP: 3.44160
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 281.116426730
• Heavy Atom Count: 21
• Complexity: 357

Purity/Quality:

98%min ^*data from raw suppliers

5-(BENZYLOXY)-1H-INDOLE-2-CARBOHYDRAZIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC3=C(C=C2)NC(=C3)C(=O)NN

Technology Process of 5-(benzyloxy)-1H-indole-2-carbohydrazide

There total 2 articles about 5-(benzyloxy)-1H-indole-2-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-benzyloxy-1H-indole-2-carboxylic acid ethyl ester (37033-95-7) → 5-benzyloxy-indole-2-carboxylic acid hydrazide (20948-66-7)

Guidance literature:

With hydrazine hydrate; In ethanol; Heating;

Reference yield:

→ 5-benzyloxy-indole-2-carboxylic acid hydrazide (20948-66-7)

Guidance literature:

Reference yield: 96.0%

1,4-dihydro-4-oxoquinoline-3-carbaldehyde (7509-12-8,83342-70-5) + 5-benzyloxy-indole-2-carboxylic acid hydrazide (20948-66-7) → (E)-5-(benzyloxy)-N-[(4-hydroxyquinolin-3-yl)methylene]-1H-indole-2-carbohydrazide

Guidance literature:

In ethanol; Reflux; Inert atmosphere;

DOI:10.1002/ejoc.201402837

upstream raw materials:

5-benzyloxy-1H-indole-2-carboxylic acid ethyl ester

Downstream raw materials:

5-benzyloxy-indole-2-carboxylic acid benzylidenehydrazide

5-Benzyloxy-1H-indole-2-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

5-(5-Benzyloxy-1H-indol-2-yl)-3H-[1,3,4]oxadiazole-2-thione

8-Benzyloxy-1-methyl-3,5-dihydro-pyridazino[4,5-b]indol-4-one