4'-(4-FLUOROPHENYL)-2,2':6',2''-TERPYRIDINE

Base Information

• Chemical Name: 4'-(4-FLUOROPHENYL)-2,2':6',2''-TERPYRIDINE
• CAS No.: 209901-86-0
• Molecular Formula: C21H14FN3
• Molecular Weight: 327.361
• Mol file: 209901-86-0.mol

Synonyms:4'-(2-fluorophenyl)-2,2':6',2''-terpyridine;2,2':6',2''-Terpyridine,4'-(4-fluorophenyl);4'-(p-FC6H4)(2,2':6',2''-terpyridine);4'-(4-fluorophenyl)-2,2':6',2''-terpyridine;

Chemical Property of 4'-(4-FLUOROPHENYL)-2,2':6',2''-TERPYRIDINE

Chemical Property:

• Melting Point: 184-185 °C(Solv: ethanol (64-17-5))
• Boiling Point: 473.3oC at 760 mmHg
• PKA: 4.51±0.29(Predicted)
• Flash Point: 240oC
• PSA: 38.67000
• Density: 1.216g/cm3
• LogP: 5.01170
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4'-(4-Fluorophenyl)-2,2':6',2''-terpyridine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-(4-FLUOROPHENYL)-2,2':6',2''-TERPYRIDINE

There total 1 articles about 4'-(4-FLUOROPHENYL)-2,2':6',2''-TERPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-acetylpyridine (1122-62-9) + 4-fluorobenzaldehyde (459-57-4) → 4′-(4-fluorophenyl)-2,2′:6′,2′′-terpyridine (209901-86-0)

Guidance literature:

With ammonium acetate; In water; at 130 ℃; for 0.3h; microwave irradiation;

DOI:10.1016/j.tet.2006.10.069

Reference yield: 88.0%

4′-(4-fluorophenyl)-2,2′:6′,2′′-terpyridine (209901-86-0) + ammonium hexafluorophosphate + iron(II) sulfate hexahydrate (42120-27-4) → [Fe(4'-(4-fluorophenyl)-2,2':6',2''-terpyridine)2][PF6]2

Guidance literature:

In methanol; refluxing metal salt with 2 equiv. ligand for 10 min, addn. of NH4PF6 (pptn.); collection (filtration), recrystn. (Et2O diffusion into Me2CO soln.); elem. anal.;

DOI:10.1016/s0020-1693(98)00075-9

Reference yield: 87.0%

4′-(4-fluorophenyl)-2,2′:6′,2′′-terpyridine (209901-86-0) + sodium hexaflorophosphate + tris(triphenylphosphine)ruthenium(II) chloride (15529-49-4,41756-81-4) → C57H44ClFN3P2Ru(1+)*F6P(1-)

Guidance literature:

4′-(4-fluorophenyl)-2,2′:6′,2′′-terpyridine; tris(triphenylphosphine)ruthenium(II) chloride; In methanol; for 24h; Inert atmosphere; Schlenk technique; Reflux;

sodium hexaflorophosphate; In methanol; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1021/acs.inorgchem.8b02440

upstream raw materials:

2-acetylpyridine

4-fluorobenzaldehyde

Downstream raw materials:

[Cu(ciprofloxacin)(4'-(4-fluorophenyl)-2,2':6',2''-terpyridine)Cl]

CuCl(1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylate)(4'-(4-fluorophenyl)-2,2':6',2''-terpyridine)