2-(3-CYANO-4-FLUORO-PHENYL)-5-TRIFLUORO-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID

Base Information

Chemical Name:2-(3-CYANO-4-FLUORO-PHENYL)-5-TRIFLUORO-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
CAS No.:209960-58-7
Molecular Formula:C12H5F4N3O2
Molecular Weight:299.184
Hs Code.:
Mol file:209960-58-7.mol

Synonyms:1-(3-cyano-4-fluorophenyl)-3-trifluoromethyl-5-hydroxycarbonyl pyrazole;2-(3-Cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid;1-(4-fluoro-3-cyanophenyl)-3-trifluoromethyl-5-hydroxycarbonylpyrazole;1-(4-fluoro-3-cyano)phenyl-3-trifluoromethylpyrazole-5-carboxylic acid;1-(4-fluoro-3-cyanophenyl)-3-trifluoromethyl-5-pyrazolecarboxylic acid;1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid;1-(4'-fluoro-3'-cyanophenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid;

Suppliers and Price of 2-(3-CYANO-4-FLUORO-PHENYL)-5-TRIFLUORO-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 7 raw suppliers

Chemical Property of 2-(3-CYANO-4-FLUORO-PHENYL)-5-TRIFLUORO-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID

Chemical Property:

PSA：78.91000
LogP:2.60008

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Technology Process of 2-(3-CYANO-4-FLUORO-PHENYL)-5-TRIFLUORO-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID

There total 5 articles about 2-(3-CYANO-4-FLUORO-PHENYL)-5-TRIFLUORO-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 335275-96-2
ethyl 1-(4-fluoro-3-cyano)phenyl-3-trifluoromethylpyrazole-5-carboxylate

: 209960-58-7
1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid

Guidance literature:: ethyl 1-(4-fluoro-3-cyano)phenyl-3-trifluoromethylpyrazole-5-carboxylate; With sodium hydroxide; water; In tetrahydrofuran; at 5 - 10 ℃;

With acetic acid; In water; at 5 - 50 ℃; for 1h;

Reference yield:

: 335275-96-2
ethyl 1-(4-fluoro-3-cyano)phenyl-3-trifluoromethylpyrazole-5-carboxylate

: 209960-58-7
1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid

: 1-(4-Fluoro-3-cyano)phenyl-3-trifluoramethylpyrazole-5-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; In THF-MeOH-H₂O; water; ethyl acetate;

Reference yield:

: 17417-09-3
2-fluoro-5-nitrobenzonitrile

: 209960-58-7
1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 85 percent / SnCl₂*2H₂O / ethyl acetate / 1.5 h / Heating

2.1: NaNO₂; aq. HCl / 0.5 h / 0 °C

2.2: stannous chloride; aq. HCl / 12 h / 0 °C

2.3: 7.0 g / acetic acid / 12 h / Heating

3.1: 64 percent / RuCl₃; aq. NaIO₄ / acetonitrile; CCl₄ / 12 h / 20 °C

With hydrogenchloride; ruthenium trichloride; sodium periodate; tin(ll) chloride; sodium nitrite; In tetrachloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm0497949