2-Propenoic acid, 2-fluoro-3-(2-naphthalenyl)-, ethyl ester, (2Z)-

Base Information

• Chemical Name: 2-Propenoic acid, 2-fluoro-3-(2-naphthalenyl)-, ethyl ester, (2Z)-
• CAS No.: 212078-41-6
• Molecular Formula: C15H13FO2
• Molecular Weight: 244.265
• Mol file: 212078-41-6.mol

Synonyms:

Chemical Property of 2-Propenoic acid, 2-fluoro-3-(2-naphthalenyl)-, ethyl ester, (2Z)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenoic acid, 2-fluoro-3-(2-naphthalenyl)-, ethyl ester, (2Z)-

There total 1 articles about 2-Propenoic acid, 2-fluoro-3-(2-naphthalenyl)-, ethyl ester, (2Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ ethyl (Z)-2-fluoro-3-(2-naphthyl)-2-propenoate (212078-41-6) + ethyl 2-fluoro-2-(phenylsulfinyl)acetate (129599-90-2)

Guidance literature:

Reference yield:

ethyl (Z)-2-fluoro-3-(2-naphthyl)-2-propenoate (212078-41-6) → (Z)-2-(1-fluoro-2-(naphthalen-2-yl)vinyl)-5-phenyl-1,3,4-oxadiazole

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; water / ethanol / 18 h / Reflux; Inert atmosphere

2: 1,2-bis-(diphenylphosphino)ethane; palladium(II) acetylacetonate; copper(II) carbonate / N,N-dimethyl acetamide; dimethyl sulfoxide / 12 h / 140 °C / Molecular sieve; Inert atmosphere

With copper(II) carbonate; palladium(II) acetylacetonate; water; 1,2-bis-(diphenylphosphino)ethane; potassium hydroxide; In ethanol; N,N-dimethyl acetamide; dimethyl sulfoxide;

DOI:10.1002/chem.201405119

Reference yield:

ethyl (Z)-2-fluoro-3-(2-naphthyl)-2-propenoate (212078-41-6) → (Z)-2-(1-fluoro-2-(naphthalen-2-yl)vinyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; water / ethanol / 18 h / Reflux; Inert atmosphere

2: 1,2-bis-(diphenylphosphino)ethane; palladium(II) acetylacetonate; copper(II) carbonate / N,N-dimethyl acetamide; dimethyl sulfoxide / 12 h / 140 °C / Molecular sieve; Inert atmosphere

With copper(II) carbonate; palladium(II) acetylacetonate; water; 1,2-bis-(diphenylphosphino)ethane; potassium hydroxide; In ethanol; N,N-dimethyl acetamide; dimethyl sulfoxide;

DOI:10.1002/chem.201405119