3-Oxazolidinecarboxylic acid, 4-[(1S)-1-[hydroxy(phenylmethyl)amino]-3-(trimethylsilyl)-2-propynyl]-2,2 -dimethyl-, 1,1-dimethylethyl ester, (4R)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 4-[(1S)-1-[hydroxy(phenylmethyl)amino]-3-(trimethylsilyl)-2-propynyl]-2,2 -dimethyl-, 1,1-dimethylethyl ester, (4R)-
CAS No.:212330-22-8
Molecular Formula:C23H36N2O4Si
Molecular Weight:432.635
Hs Code.:
Mol file:212330-22-8.mol

3-Oxazolidinecarboxylic acid,
4-[(1S)-1-[hydroxy(phenylmethyl)amino]-3-(trimethylsilyl)-2-propynyl]-2,2
-dimethyl-, 1,1-dimethylethyl ester, (4R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Oxazolidinecarboxylic acid, 4-[(1S)-1-[hydroxy(phenylmethyl)amino]-3-(trimethylsilyl)-2-propynyl]-2,2 -dimethyl-, 1,1-dimethylethyl ester, (4R)-

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Oxazolidinecarboxylic acid, 4-[(1S)-1-[hydroxy(phenylmethyl)amino]-3-(trimethylsilyl)-2-propynyl]-2,2 -dimethyl-, 1,1-dimethylethyl ester, (4R)-

There total 1 articles about 3-Oxazolidinecarboxylic acid, 4-[(1S)-1-[hydroxy(phenylmethyl)amino]-3-(trimethylsilyl)-2-propynyl]-2,2 -dimethyl-, 1,1-dimethylethyl ester, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 54655-07-1
lithium trimethylsilylacetylenide

: 158723-45-6,188965-45-9
(Z)-N-[(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]benzylamine N-oxide

: 212330-22-8
(R)-4-[(S)-1-(Benzyl-hydroxy-amino)-3-trimethylsilanyl-prop-2-ynyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: In tetrahydrofuran; at -80 ℃; for 0.25h;
DOI:10.1021/jo9714775

Reference yield:

: 212330-22-8
(R)-4-[(S)-1-(Benzyl-hydroxy-amino)-3-trimethylsilanyl-prop-2-ynyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 212330-24-0
(3S,4R)-3-(N-acetoxy-N-benzylamino)-5-hydroxy-4,5-N,O-isopropylidene-4-[(tert-butoxycarbonyl)amino]-1-pentyne

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / Bu₄NF / tetrahydrofuran / 1 h / Ambient temperature

2: 100 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9714775

Reference yield:

: 212330-22-8
(R)-4-[(S)-1-(Benzyl-hydroxy-amino)-3-trimethylsilanyl-prop-2-ynyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: C₂₁H₃₀N₂O₇

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / Bu₄NF / tetrahydrofuran / 1 h / Ambient temperature

2: 100 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

3: NaIO₄, RuCl₃*H₂O / acetonitrile; CCl₄; H₂O / 0.08 h

With pyridine; ruthenium trichloride; sodium periodate; tetrabutyl ammonium fluoride; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/jo9714775