1-(p-Chlorophenyl)cyclopentanemethanol

Base Information

• Chemical Name: 1-(p-Chlorophenyl)cyclopentanemethanol
• CAS No.: 80866-79-1
• Molecular Formula: C12H15 Cl O
• Molecular Weight: 210.704
• Hs Code.: 2906299090
• European Community (EC) Number: 279-583-0
• DSSTox Substance ID: DTXSID201001594
• Nikkaji Number: J320.326C
• Wikidata: Q82995565
• Mol file: 80866-79-1.mol

Synonyms:80866-79-1;[1-(4-chlorophenyl)cyclopentyl]methanol;1-(p-Chlorophenyl)cyclopentanemethanol;(1-(4-Chlorophenyl)cyclopentyl)methanol;EINECS 279-583-0;SCHEMBL5873448;JPVGEFSYKNYYAU-UHFFFAOYSA-N;DTXSID201001594;AKOS023422049;1-(4-Chlorophenyl)cyclopentanemethanol;TS-03000;[1-(4-chlorophenyl)-cyclopentyl]-methanol;[1-(4-chlorophenyl)-1-cyclopentyl]methanol;CS-0362744

Chemical Property of 1-(p-Chlorophenyl)cyclopentanemethanol

Chemical Property:

• Vapor Pressure: 0.0002mmHg at 25°C
• Boiling Point: 314.3°C at 760 mmHg
• Flash Point: 143.9°C
• PSA: 20.23000
• Density: 1.158g/cm³
• LogP: 3.14410
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 210.0811428
• Heavy Atom Count: 14
• Complexity: 179

Purity/Quality:

99% ^*data from raw suppliers

[1-(4-Chlorophenyl)cyclopentyl]methanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C1)(CO)C2=CC=C(C=C2)Cl

Technology Process of 1-(p-Chlorophenyl)cyclopentanemethanol

There total 5 articles about 1-(p-Chlorophenyl)cyclopentanemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(4-chlorophenyl)-1-cyclopentanecarboxylic acid methyl ester (914106-85-7) → <1-(p-Chlorophenyl)cyclopentyl>carbinol (80866-79-1)

Guidance literature:

With lithium aluminium tetrahydride; for 6h; Cooling with ice; Reflux;

Reference yield: 92.0%

1-(4-chlorophenyl)cyclopentane-1-carboxylic acid (80789-69-1) → <1-(p-Chlorophenyl)cyclopentyl>carbinol (80866-79-1)

Guidance literature:

With borane-THF; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1021/jo00100a060

Reference yield: 69.0%

1-(4-chlorophenyl)cyclopentane-1-carbaldehyde (189810-98-8) → <1-(p-Chlorophenyl)cyclopentyl>carbinol (80866-79-1)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 2h; Time;

upstream raw materials:

1-(4-chlorophenyl)cyclopentane-1-carboxylic acid

1-(4-chlorophenyl)cyclopentanecarboxylic acid

p-chlorobenzyl cyanide

1-(4-chlorophenyl)cyclopentane-1-carbaldehyde

Downstream raw materials:

[1-(4-chlorophenyl)cyclopentyl]acetonitrile

methanesulfonic acid 1-(4-chlorophenyl)cyclopentylmethyl ester

<1-(p-Chlorophenyl)cyclopentyl>carbinyl tosylate

1-(4-chlorophenyl)cyclopentane-1-carbaldehyde

Refernces

• 1、 -. "PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE". . . Retrieved 2014/07/22.
• 2、 Roberts, Donald D.,Arant, Mark E.. "Solvolysis Reactions: Relative Abilities of Cyclopentyl/Phenyl Groups To Stabilize an Electron-Deficient Carbon". . p. 6464 - 6469. Retrieved 2007/10/02.