ETHYL 3-OXO-3-THIAZOL-2-YL-PROPIONATE

Base Information

• Chemical Name: ETHYL 3-OXO-3-THIAZOL-2-YL-PROPIONATE
• CAS No.: 212621-63-1
• Molecular Formula: C8H9NO3S
• Molecular Weight: 199.22700
• Hs Code.: 2934100090
• Mol file: 212621-63-1.mol

Synonyms:ethyl 2-thiazoloyl-acetate;3-Oxo-3-thiazol-2-yl-propionic acid ethyl ester;ETHYL 3-OXO-3-THIAZOL-2-YL-PROPIONATE;

Chemical Property of ETHYL 3-OXO-3-THIAZOL-2-YL-PROPIONATE

Chemical Property:

• Vapor Pressure: 0.000658mmHg at 25°C
• Boiling Point: 309oC at 760 mmHg
• PKA: 9.31±0.50(Predicted)
• Flash Point: 140.7oC
• PSA: 84.50000
• Density: 1.271g/cm3
• LogP: 1.27900

Purity/Quality:

98% ^*data from raw suppliers

Ethyl3-Oxo-3-thiazol-2-yl-propionate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 3-OXO-3-THIAZOL-2-YL-PROPIONATE

There total 3 articles about ETHYL 3-OXO-3-THIAZOL-2-YL-PROPIONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,3-thiazole-2-carboxylic acid (14190-59-1) + ethyl potassium malonate (6148-64-7) → 3-oxo-3-thiazol-2-yl-propionic acid ethyl ester (212621-63-1)

Guidance literature:

1,3-thiazole-2-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

ethyl potassium malonate; With magnesium chloride; In tetrahydrofuran; at 50 - 75 ℃; for 20h;

Reference yield: 90.0%

2-Acetylthiazole (24295-03-2,260998-74-1) + Diethyl carbonate (105-58-8,76619-83-5) → 3-oxo-3-thiazol-2-yl-propionic acid ethyl ester (212621-63-1)

Guidance literature:

With sodium hydride; In mineral oil; at 20 - 90 ℃; for 3h;

DOI:10.1016/j.bmcl.2016.01.006

Reference yield: 56.0%

→ 3-oxo-3-thiazol-2-yl-propionic acid ethyl ester (212621-63-1)

Guidance literature:

upstream raw materials:

2-Acetylthiazole

Diethyl carbonate

1,3-thiazole-2-carboxylic acid

ethyl potassium malonate

Refernces

• 1、 Slee, Deborah H.,Zhang, Xiaohu,Moorjani, Manisha,Lin, Emily,Lanier, Marion C.,Chen, Yongsheng,Rueter, Jaimie K.,Lechner, Sandra M.,Markison, Stacy,Malany, Siobhan,Joswig, Tanya,Santos, Mark,Gross, Raymond S.,Williams, John P.,Castro-Palomino, Julio C.,Crespo, María I.,Prat, Maria,Gual, Silvia,Díaz, José-Luis,Wen, Jenny,O'Brien, Zhihong,Saunders, John. "Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy". . p. 400 - 406. Retrieved 2008.
• 2、 Blackwell, Helen E.,Manson, Daniel E.,Nyffeler, Kayleigh E.,O'Reilly, Matthew C.. "Design, Synthesis, and Biochemical Characterization of Non-Native Antagonists of the Pseudomonas aeruginosa Quorum Sensing Receptor LasR with Nanomolar IC50 Values". . . Retrieved 2020/03/04.
• 3、 -. "AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS". Paragraph 0357. . Retrieved 2018/08/12.