Technology Process of Spiro[5.5]undecan-3-amine;chloride
There total 5 articles about Spiro[5.5]undecan-3-amine;chloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
spiro[5.5]undecan-3-one oxime;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
Inert atmosphere;
Reflux;
With
hydrogenchloride;
In
tetrahydrofuran; 1,4-dioxane;
Inert atmosphere;
DOI:10.1021/ja204969m
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylsilane; palladium dichloride / 6 h / Reflux; Inert atmosphere
2.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 2 h / Reflux; Inert atmosphere
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux
3.2: Inert atmosphere
With
triethylsilane; lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium acetate; palladium dichloride;
In
tetrahydrofuran; ethanol;
DOI:10.1021/ja204969m
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 2 h / Reflux; Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux
2.2: Inert atmosphere
With
lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium acetate;
In
tetrahydrofuran; ethanol;
DOI:10.1021/ja204969m
