[(3S,4S)-4-(4-Chlorophenyl)-1-methylpiperidin-3-YL]methanol

Base Information

Chemical Name:[(3S,4S)-4-(4-Chlorophenyl)-1-methylpiperidin-3-YL]methanol
CAS No.:214335-19-0
Molecular Formula:C13H18ClNO
Molecular Weight:239.745
Hs Code.:
DSSTox Substance ID:DTXSID70441461
Nikkaji Number:J964.704J
Wikidata:Q82258232
Mol file:214335-19-0.mol

Synonyms:214335-19-0;[(3S,4S)-4-(4-CHLOROPHENYL)-1-METHYLPIPERIDIN-3-YL]METHANOL;SCHEMBL3833872;DTXSID70441461;1-Methyl-4beta-(4-chlorophenyl)piperidine-3beta-methanol

Suppliers and Price of [(3S,4S)-4-(4-Chlorophenyl)-1-methylpiperidin-3-YL]methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of [(3S,4S)-4-(4-Chlorophenyl)-1-methylpiperidin-3-YL]methanol

Chemical Property:

PSA：23.47000
LogP:2.30550
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:239.1076919
Heavy Atom Count:16
Complexity:216

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC(C(C1)CO)C2=CC=C(C=C2)Cl
Isomeric SMILES:CN1CC[C@@H]([C@@H](C1)CO)C2=CC=C(C=C2)Cl

Technology Process of [(3S,4S)-4-(4-Chlorophenyl)-1-methylpiperidin-3-YL]methanol

There total 4 articles about [(3S,4S)-4-(4-Chlorophenyl)-1-methylpiperidin-3-YL]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 214335-16-7,205805-13-6
(-)-Methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3β-carboxylate

: 214335-19-0
(3S,4S)-4-(4-chlorophenyl)-3-(hydroxymethyl)-1-methylpiperidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/S0960-894X(99)00562-4

Reference yield:

: 63-75-2
arecoline

: 214335-19-0
(3S,4S)-4-(4-chlorophenyl)-3-(hydroxymethyl)-1-methylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / diethyl ether / 0.5 h / -10 °C

3: 98 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm980028+

Reference yield:

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 214335-19-0
(3S,4S)-4-(4-chlorophenyl)-3-(hydroxymethyl)-1-methylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / diethyl ether / 0.5 h / -10 °C

3: 98 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm980028+