3-Quinolinecarbonitrile, 4-chloro-6-Methoxy-7-[3-(4-Morpholinyl)propoxy]-

Base Information

• Chemical Name: 3-Quinolinecarbonitrile, 4-chloro-6-Methoxy-7-[3-(4-Morpholinyl)propoxy]-
• CAS No.: 214487-30-6
• Molecular Formula: C18H20ClN3O3
• Molecular Weight: 361.828
• Mol file: 214487-30-6.mol

Synonyms:4-chloro-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline-3-carbonitrile;3-Quinolinecarbonitrile, 4-chloro-6-methoxy-7-[3-(4-morpholinyl)propoxy]-;4-chloro-3-cyano-6-methoxy-7-(3-morpholinopropoxy)quinoline;

Chemical Property of 3-Quinolinecarbonitrile, 4-chloro-6-Methoxy-7-[3-(4-Morpholinyl)propoxy]-

Chemical Property:

• PSA: 67.61000
• LogP: 2.80748

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Quinolinecarbonitrile, 4-chloro-6-Methoxy-7-[3-(4-Morpholinyl)propoxy]-

There total 2 articles about 3-Quinolinecarbonitrile, 4-chloro-6-Methoxy-7-[3-(4-Morpholinyl)propoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

4-(3-chloropropyl)morpholine (7357-67-7) + 4-chloro-7-hydroxy-6-methoxyquinolin-3-carbonitrile (263149-10-6) → (4-chloro-6-methoxy-7-[3-(1-morpholino)propoxy]-3-quinolinecarbonitrile) (214487-30-6)

Guidance literature:

With potassium carbonate; In butanone; at 88 ℃; for 96h;

Reference yield:

3-morpholin-4-ylpropan-1-ol (4441-30-9) + 4-chloro-7-hydroxy-6-methoxyquinolin-3-carbonitrile (263149-10-6) → (4-chloro-6-methoxy-7-[3-(1-morpholino)propoxy]-3-quinolinecarbonitrile) (214487-30-6)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2007.07.071

Reference yield: 90.0%

2,4-dimethyl-5-methoxyaniline (380844-06-4) + (4-chloro-6-methoxy-7-[3-(1-morpholino)propoxy]-3-quinolinecarbonitrile) (214487-30-6) → 6-methoxy-4-(5-methoxy-2,4-dimethyl-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinoline-3-carbonitrile

Guidance literature:

With pyridine hydrochloride; In 2-ethoxy-ethanol; for 3h; Heating;

DOI:10.1021/jm0102250

upstream raw materials:

3-morpholin-4-ylpropan-1-ol

4-chloro-7-hydroxy-6-methoxyquinolin-3-carbonitrile

4-(3-chloropropyl)morpholine

Downstream raw materials:

4-(2,4-dichloro-phenylamino)-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline-3-carbonitrile