6,7-dimethoxy-N-phenylquinazolin-4-amine

Base Information

Chemical Name:6,7-dimethoxy-N-phenylquinazolin-4-amine
CAS No.:21561-09-1
Molecular Formula:C16H15N3O2
Molecular Weight:281.314
Hs Code.:
DSSTox Substance ID:DTXSID80274409
Nikkaji Number:J1.102.441F
Wikidata:Q82003768
Pharos Ligand ID:5W9YJXGYVNDV
ChEMBL ID:CHEMBL94191
Mol file:21561-09-1.mol

Synonyms:21561-09-1;WHI-P258;6,7-dimethoxy-N-phenylquinazolin-4-amine;4-Phenylamino-6,7-dimethoxyquinazoline;CHEMBL94191;4-Quinazolinamine, 6,7-dimethoxy-N-phenyl-;6,7-dimethoxy-N-phenyl-4-quinazolinamine;Oprea1_506594;BDBM3530;SCHEMBL1257431;WHI-P 258;DTXSID80274409;HMS1662N04;BCP15149;EX-A1237;WAA56109;MFCD01815294;s6521;AKOS002350879;N-Phenyl-6,7-dimethoxyquinazoline-4-amine;HY-108419;4-(phenyl)-amino-6,7-dimethoxy-quinazoline;CS-0028609;11N-058;SR-02000000179;SR-02000000179-1

Suppliers and Price of 6,7-dimethoxy-N-phenylquinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Phenylamino-6,7-dimethoxyquinazoline
50mg
$ 415.00

DC Chemicals
WHI-P258 >98%
250 mg
$ 850.00

Crysdot
6,7-Dimethoxy-N-phenylquinazolin-4-amine 95+%
1g
$ 660.00

ChemScene
WHI-P258 99.80%
50mg
$ 390.00

ChemScene
WHI-P258 99.80%
100mg
$ 650.00

ChemScene
WHI-P258 99.80%
2mg
$ 50.00

Chemenu
6,7-Dimethoxy-N-phenylquinazolin-4-amine 95%
1g
$ 617.00

Cayman Chemical
WHI-P258 ≥98%
5mg
$ 760.00

Cayman Chemical
WHI-P258 ≥98%
1mg
$ 171.00

Cayman Chemical
WHI-P258 ≥98%
500μg
$ 95.00

Total 19 raw suppliers

Chemical Property of 6,7-dimethoxy-N-phenylquinazolin-4-amine

Chemical Property:

Boiling Point:441.2±40.0 °C(Predicted)
PKA:6.19±0.70(Predicted)
PSA：56.27000
Density:1?+-.0.06 g/cm3(Predicted)
LogP:3.46360
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:281.116426730
Heavy Atom Count:21
Complexity:323

Purity/Quality:

99%, ^*data from raw suppliers

4-Phenylamino-6,7-dimethoxyquinazoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC=C3)OC
Description WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated Ki value of 72 μM. However, it is inactive at JAK3 (IC50 = >300 μM) and has been used as a negative control for structurally similar compounds that inhibit platelet aggregation and herpes simplex virus 1 (HSV-1) replication.
Uses 4-Phenylamino-6,7-dimethoxyquinazoline is a specific inhibitors of Janus kinase 3 (JAK3).

Technology Process of 6,7-dimethoxy-N-phenylquinazolin-4-amine

There total 4 articles about 6,7-dimethoxy-N-phenylquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 62-53-3
aniline

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 21561-09-1
6,7-dimethoxy-4-phenylaminoquinazoline

Guidance literature:: In acetonitrile; at 100 ℃; for 24h;
DOI:10.1016/j.bmcl.2011.01.037

Reference yield: 79.0%

: 21561-09-1
6,7-dimethoxy-4-phenylaminoquinazoline

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 5653-40-7
2-Amino-4,5-dimethoxybenzoic acid

: 21561-09-1
6,7-dimethoxy-4-phenylaminoquinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: 20 percent / 2 h / 170 °C

2: 57 percent / POCl₃, dimethylaniline / toluene / 4 h / Heating

3: 2.) aq. satd. Na₂CO₃ / ethanol / 0.5 h / Heating

With sodium carbonate; 2,3-Dimethylaniline; trichlorophosphate; In ethanol; toluene;
DOI:10.1016/0968-0896(96)00107-1