Cytidine, N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-5'-O-[bis(4-methoxy phenyl)phenylmethyl]-2'-deoxy-

Base Information

• Chemical Name: Cytidine, N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-5'-O-[bis(4-methoxy phenyl)phenylmethyl]-2'-deoxy-
• CAS No.: 215650-50-3
• Molecular Formula: C40H54N6O6
• Mol file: 215650-50-3.mol

Synonyms:

Chemical Property of Cytidine, N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-5'-O-[bis(4-methoxy phenyl)phenylmethyl]-2'-deoxy-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cytidine, N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-5'-O-[bis(4-methoxy phenyl)phenylmethyl]-2'-deoxy-

There total 1 articles about Cytidine, N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-5'-O-[bis(4-methoxy phenyl)phenylmethyl]-2'-deoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Spermine (71-44-3) + 5'-O-dimethoxytrityl-4-N-p-toluenesulfonyl-2'-deoxycytidine (147139-43-3) → 4-{3-[4-(3-Amino-propylamino)-butylamino]-propylamino}-1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one (215650-50-3)

Guidance literature:

With pyridine; at 70 ℃; for 17h;

DOI:10.1080/07328319808004725

Reference yield:

4-{3-[4-(3-Amino-propylamino)-butylamino]-propylamino}-1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one (215650-50-3) → 5'-O-dimethoxytrityl-4-N-(tris(N,N',N-trifluoroacetyl)-4,9,13-triazatridecane-1-yl)-2'-deoxycytidine 3'-phosphoramidite

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0.08 h / Ambient temperature

2: 81 percent / tetrazole / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; 1H-tetrazole; In dichloromethane;

DOI:10.1080/07328319808004725

Reference yield:

trifluoroacetic anhydride (407-25-0) + 4-{3-[4-(3-Amino-propylamino)-butylamino]-propylamino}-1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one (215650-50-3) → C46H51F9N6O9 (215650-54-7)

Guidance literature:

With pyridine; for 0.0833333h; Yield given; Ambient temperature;

DOI:10.1080/07328319808004725

upstream raw materials:

Spermine

5'-O-dimethoxytrityl-4-N-p-toluenesulfonyl-2'-deoxycytidine

Downstream raw materials:

C₄₆H₅₁F₉N₆O₉