2,7-Octadiyn-1-ol, 8-phenyl-

Base Information

Chemical Name:2,7-Octadiyn-1-ol, 8-phenyl-
CAS No.:217083-10-8
Molecular Formula:C14H14O
Molecular Weight:198.265
Hs Code.:
Mol file:217083-10-8.mol

Synonyms:

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Chemical Property of 2,7-Octadiyn-1-ol, 8-phenyl-

Chemical Property:

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Technology Process of 2,7-Octadiyn-1-ol, 8-phenyl-

There total 7 articles about 2,7-Octadiyn-1-ol, 8-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 591-50-4
iodobenzene

: 32080-48-1
octa-2,7-diyn-1-ol

: 217083-10-8
1-phenyl-1,6-octadiyn-8-ol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1021/jo020649h

Reference yield:

: 2396-63-6
hepta-1,6-diyne

: 217083-10-8
1-phenyl-1,6-octadiyn-8-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethylmagnesium bromide / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere; Schlenk technique

1.2: 10 h / 20 °C / Inert atmosphere; Schlenk technique

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 9 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ethylmagnesium bromide; triethylamine; In tetrahydrofuran;
DOI:10.1021/jacs.1c07556

Reference yield:

: 5390-04-5
pent-1-yn-5-ol

: 217083-10-8
1-phenyl-1,6-octadiyn-8-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: hexane; tetrahydrofuran / -78 - 20 °C

1.3: 10percent aq. HCl / hexane; tetrahydrofuran / 4 h / 20 °C

2.1: PPh₃; imidazole; I₂ / CH₂Cl₂ / 2 h / 20 °C

3.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

3.2: hexane; tetrahydrofuran / -78 - 50 °C

4.1: 211 mg / 10percent aq. HCl / methanol / 12 h / 20 °C

5.1: 72 percent / TBAF / tetrahydrofuran / 4 h / 20 °C

6.1: 82 percent / CuI; iPr₂NH; PdCl₂(PPh₃)2 / tetrahydrofuran / 18 h / 20 °C

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; tetrabutyl ammonium fluoride; iodine; diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jo020649h