Chemical Property of Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-
Chemical Property:
- Boiling Point:593.5±50.0 °C(Predicted)
- PKA:13.66±0.70(Predicted)
- PSA：88.89000
- Density:1.346±0.06 g/cm3(Predicted)
- LogP:3.54400
- Storage Temp.:2-8°C
- Solubility.:DMSO: ≥25mg/mL
- Purity/Quality:
-
99%, *data from raw suppliers
BX 471 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn,N
- Statements:
22-50
- Safety Statements:
61
- MSDS Files:
-
SDS file from LookChem
Useful:
-
Description
The CC chemokine receptor-1 (CCR1), whose ligands include macrophage inflammatory protein-1α (MIP-1α), RANTES, and monocyte chemotactic protein-3 (MCP-3), has a central role in leukocyte trafficking and is highly expressed in certain autoimmune diseases. BX 471 is a nonpeptide CCR1 antagonist that has been shown to displace MIP-1α, RANTES, and MCP-3 with Ki values of 1, 2.8, and 5.5 nM, respectively. It demonstrates >10,000-fold selectivity for CCR1 over 28 additional G protein-coupled receptors, including related chemokine receptors. In a rat experimental allergic encephalomyelitis model of multiple sclerosis, BX 471 at 50 mg/kg was shown to significantly reduce the severity of the disease. BX 471 also decreases the inflammatory response during sepsis, blocks migration of monocytes isolated from rheumatoid arthritis patients, and prevents macrophage and T-cell recruitment in a mouse model of lupus nephritis.
-
Uses
BX471 has been used in chemotaxis assay to study the responses of HEK293 cells expressing human C-C motif chemokine receptor 1 (CCR1) to CC motif ligand 3 (CCL3)-induced cell migration. It has also been used as a CCR1 inhibitor to assess the effects of CCR1 on the migration and epithelial-mesenchymal transition (EMT).
