H-β³hVal-β³hLys-β³hSer(All)-β³hPhe-β³hGlu-β³hSer(All)-β³hTyr-β³hIle-OH

Base Information

• Chemical Name: H-β³hVal-β³hLys-β³hSer(All)-β³hPhe-β³hGlu-β³hSer(All)-β³hTyr-β³hIle-OH
• CAS No.: 1207682-51-6
• Molecular Formula: C₆₀H₉₃N₉O₁₄
• Molecular Weight: 1164.45
• Mol file: 1207682-51-6.mol

Synonyms:

Chemical Property of H-β³hVal-β³hLys-β³hSer(All)-β³hPhe-β³hGlu-β³hSer(All)-β³hTyr-β³hIle-OH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-β³hVal-β³hLys-β³hSer(All)-β³hPhe-β³hGlu-β³hSer(All)-β³hTyr-β³hIle-OH

There total 1 articles about H-β³hVal-β³hLys-β³hSer(All)-β³hPhe-β³hGlu-β³hSer(All)-β³hTyr-β³hIle-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-(allyloxy)butanoic acid (1135148-98-9) + C22H24NO4Pol + Fmoc-β3-HVal (172695-33-9) + (S)-3-(9H-fluoren-9-yl)methoxycarbonylamino-4-phenylbutanoic acid (193954-28-8,282524-78-1) + (3S)-3-([(9H-fluoren-9-yl)methoxy]carbonyl)aminohexanedioic acid 6-(tert-butyl) ester (203854-49-3) + Fmoc-(S)-β3-HLys(Boc)-OH (203854-47-1) + (S)-3-(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)-4-<4-(tert-butoxy)phenyl>butanoic acid (219967-69-8) → H-β3hVal-β3hLys-β3hSer(All)-β3hPhe-β3hGlu-β3hSer(All)-β3hTyr-β3hIle-OH (1207682-51-6)

Guidance literature:

C₂₂H₂₄NO₄Pol; With piperidine; In N,N-dimethyl-formamide; Inert atmosphere; Large scale reaction; solid phase reaction;

(S)-3-(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)-4-<4-(tert-butoxy)phenyl>butanoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; solid phase reaction;

(R)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-(allyloxy)butanoic acid; Fmoc-β³-HVal; (S)-3-(9H-fluoren-9-yl)methoxycarbonylamino-4-phenylbutanoic acid; (3S)-3-([(9H-fluoren-9-yl)methoxy]carbonyl)aminohexanedioic acid 6-(tert-butyl) ester; Fmoc-(S)-β³-HLys(Boc)-OH; Further stages;

DOI:10.1002/hlca.200900311

upstream raw materials:

(R)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-(allyloxy)butanoic acid

Fmoc-β³-HVal

(S)-3-(9H-fluoren-9-yl)methoxycarbonylamino-4-phenylbutanoic acid

(3S)-3-([(9H-fluoren-9-yl)methoxy]carbonyl)aminohexanedioic acid 6-(tert-butyl) ester

Refernces