Chemical Property of 1-(1-(4-(7-Phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
Chemical Property:
- PSA：55.84000
- LogP:1.76120
- Storage Temp.:room temp
- Solubility.:DMSO: soluble5mg/mL, clear (warmed)
- XLogP3:1.5
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:1
- Exact Mass:245.06880783
- Heavy Atom Count:18
- Complexity:393
- Purity/Quality:
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99%, *data from raw suppliers
KNK437 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1CN(C(=O)C1=CC2=CC3=C(C=C2)OCO3)C=O
- Isomeric SMILES:C\1CN(C(=O)/C1=C\C2=CC3=C(C=C2)OCO3)C=O
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Description
KNK437 (218924-25-5) Inhibits constitutive and inducible HSP70 expression in non-stressed1 and heat-stressed2 cancer cells. Blocks the geldanamycin-induced induction of HSP70 and inhibition of TGF? signaling.3 Inhibits leukocyte integrin α4?7-mediated adhesion of T cells to mucosal addressin cell adhesion molecule 1 (MAdCAM-1) suggesting that HSP70 is essential for ?7 integrin signalling.4 Suppresses morphine analgesic tolerance in a rodent model (100 mg/Kg).5
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Uses
KNK437 has been used:as a heat shock factor 1 (HSF1) inhibitor to study its effects on the inhibition of viability and apoptosis activation in chemoresistant mice cellsas an HSF1 inhibitor to study its effects on viability and apoptosis of colorectal cancer cellsas a heat shock protein 70 (HSP70) inhibitor to study its effects on glutamine-induced HSP70 and inflammatory mediator release
