2-Oxa-5-azabicyclo[2.2.1]heptan-7-ol, 1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(3,4-dihydro-5-methyl -2,4-dioxo-1(2H)-pyrimidinyl)-5-(trifluoroacetyl)-, (1R,3R,4R,7S)-

Base Information

Chemical Name:2-Oxa-5-azabicyclo[2.2.1]heptan-7-ol, 1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(3,4-dihydro-5-methyl -2,4-dioxo-1(2H)-pyrimidinyl)-5-(trifluoroacetyl)-, (1R,3R,4R,7S)-
CAS No.:219600-96-1
Molecular Formula:C34H32F3N3O8
Molecular Weight:667.639
Hs Code.:

2-Oxa-5-azabicyclo[2.2.1]heptan-7-ol,
1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(3,4-dihydro-5-methyl
-2,4-dioxo-1(2H)-pyrimidinyl)-5-(trifluoroacetyl)-, (1R,3R,4R,7S)-

Synonyms:

Suppliers and Price of 2-Oxa-5-azabicyclo[2.2.1]heptan-7-ol, 1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(3,4-dihydro-5-methyl -2,4-dioxo-1(2H)-pyrimidinyl)-5-(trifluoroacetyl)-, (1R,3R,4R,7S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Oxa-5-azabicyclo[2.2.1]heptan-7-ol, 1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(3,4-dihydro-5-methyl -2,4-dioxo-1(2H)-pyrimidinyl)-5-(trifluoroacetyl)-, (1R,3R,4R,7S)-

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Oxa-5-azabicyclo[2.2.1]heptan-7-ol, 1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(3,4-dihydro-5-methyl -2,4-dioxo-1(2H)-pyrimidinyl)-5-(trifluoroacetyl)-, (1R,3R,4R,7S)-

There total 5 articles about 2-Oxa-5-azabicyclo[2.2.1]heptan-7-ol, 1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(3,4-dihydro-5-methyl -2,4-dioxo-1(2H)-pyrimidinyl)-5-(trifluoroacetyl)-, (1R,3R,4R,7S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 219600-95-0
1-(2-amino-2-N,4-C-methylene-2-N-trifluoroacetyl-β-D-ribofuranosyl)thymine

: 219600-96-1
1-(2-amino-5-O-4,4'-dimethoxytrityl-2-N,4-C-methylene-2-N-trifluoroacetyl-β-D-ribofuranosyl)thymine

Guidance literature:: In pyridine; dichloromethane; for 10h; Ambient temperature;
DOI:10.1021/jo9814445

Reference yield:

: 206055-57-4
1-[(2R,3R,4S,5R)-4-benzyloxy-5-(benzyloxymethyl)-3-hydroxy-5-(hydroxymethyl)tetra-hydrofuran-2-yl]-5-methylpyrimidine-2,4-dione

: 219600-96-1
1-(2-amino-5-O-4,4'-dimethoxytrityl-2-N,4-C-methylene-2-N-trifluoroacetyl-β-D-ribofuranosyl)thymine

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / DMAP / CH₂Cl₂ / 3 h / Ambient temperature

2: 52 percent / 20 h / 130 °C

3: 68 percent / ammonium formate / Pd/C / methanol / 4 h / Heating

4: 81 percent / DMAP / methanol / 2.5 h / Ambient temperature

5: 93 percent / pyridine; CH₂Cl₂ / 10 h / Ambient temperature

With dmap; ammonium formate; palladium on activated charcoal; In pyridine; methanol; dichloromethane;
DOI:10.1021/jo9814445

Reference yield:

: 213697-46-2
1-(2-amino-2-N,4-C-methylene-2-N,3-O,5-O-tribenzyl-β-D-ribofuranosyl)thymine

: 219600-96-1
1-(2-amino-5-O-4,4'-dimethoxytrityl-2-N,4-C-methylene-2-N-trifluoroacetyl-β-D-ribofuranosyl)thymine

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / ammonium formate / Pd/C / methanol / 4 h / Heating

2: 81 percent / DMAP / methanol / 2.5 h / Ambient temperature

3: 93 percent / pyridine; CH₂Cl₂ / 10 h / Ambient temperature

With dmap; ammonium formate; palladium on activated charcoal; In pyridine; methanol; dichloromethane;
DOI:10.1021/jo9814445