TERT-BUTYL 4-(AZETIDIN-3-YL)PIPERAZINE-1-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 4-(AZETIDIN-3-YL)PIPERAZINE-1-CARBOXYLATE
• CAS No.: 219725-67-4
• Molecular Formula: C₁₂H₂₃N₃O₂
• Molecular Weight: 241.334
• Hs Code.: 2933990090
• Mol file: 219725-67-4.mol

Synonyms:1-N-Boc-4-Azetidin-3-yl-piperazine;FC0199;BH268;

Chemical Property of TERT-BUTYL 4-(AZETIDIN-3-YL)PIPERAZINE-1-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.000106mmHg at 25°C
• Boiling Point: 337.3oC at 760 mmHg
• PKA: 10.81±0.40(Predicted)
• Flash Point: 157.8oC
• PSA: 44.81000
• Density: 1.115g/cm3
• LogP: 0.71550
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-(azetidin-3-yl)piperazine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: N
• Statements: 51/53
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-(AZETIDIN-3-YL)PIPERAZINE-1-CARBOXYLATE

There total 4 articles about TERT-BUTYL 4-(AZETIDIN-3-YL)PIPERAZINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyl 4-(1-((benzyloxy)carbonyl)azetidin-3-yl)piperazine-1-carboxylate (1245646-73-4) → tert-butyl 4-(azetidin-3-yl)piperazine-1-carboxylate (219725-67-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 30 ℃; for 12h; under 2585.81 Torr;

Reference yield:

tert-butyl 4-(1-benzhydrylazetidin-3-yl)piperazine-1-carboxylate (178311-82-5) → tert-butyl 4-(azetidin-3-yl)piperazine-1-carboxylate (219725-67-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 50 ℃; for 48h;

Reference yield:

1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(azetidin-3-yl)piperazine-1-carboxylate (219725-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 20 °C

2: hydrogen; palladium on activated charcoal / methanol / 2 h / 20 °C

With palladium on activated charcoal; hydrogen; sodium tris(acetoxy)borohydride; In methanol; dichloromethane;

upstream raw materials:

tert-butyl 4-(1-benzhydrylazetidin-3-yl)piperazine-1-carboxylate

1-t-Butoxycarbonylpiperazine

tert-butyl 4-(1-((benzyloxy)carbonyl)azetidin-3-yl)piperazine-1-carboxylate

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