1H-2-Benzopyran-1-one, 4-bromo-3-phenyl-

Base Information

• Chemical Name: 1H-2-Benzopyran-1-one, 4-bromo-3-phenyl-
• CAS No.: 22115-36-2
• Molecular Formula: C15H9BrO2
• Molecular Weight: 301.139
• Mol file: 22115-36-2.mol

Synonyms:4-bromo-3-phenylisocoumarin;4-bromo-3-phenyl-isochromen-1-one;4-bromo-3-phenyl-1H-isochromen-1-one;4-Bromo-3-phenyl-isocoumarin;4-Brom-3-phenyl-isocumarin;

Chemical Property of 1H-2-Benzopyran-1-one, 4-bromo-3-phenyl-

Chemical Property:

• Melting Point: 99.5-101.0 °C
• Boiling Point: 408.8±45.0 °C(Predicted)
• PSA: 30.21000
• Density: 1.571±0.06 g/cm3(Predicted)
• LogP: 4.22250

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-2-Benzopyran-1-one, 4-bromo-3-phenyl-

There total 12 articles about 1H-2-Benzopyran-1-one, 4-bromo-3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 2-(phenylethynyl)benzoate (33578-05-1) → 4-Bromo-3-phenyl-1H-benzo-2-pyran-1-one (22115-36-2)

Guidance literature:

With copper(I) bromide; In acetonitrile; for 2h; Reflux;

DOI:10.1002/jccs.200800095

Reference yield: 95.0%

methyl 2-(phenylethynyl)benzoate (33578-05-1) → 3-phenyl-isocoumarin (4809-08-9) + 4-Bromo-3-phenyl-1H-benzo-2-pyran-1-one (22115-36-2)

Guidance literature:

With copper(ll) bromide; In 1,2-dichloro-ethane; at 80 ℃; for 1h;

DOI:10.1055/s-2006-958960

Reference yield: 90.0%

methyl 2-(phenylethynyl)benzoate (33578-05-1) → 4-Bromo-3-phenyl-1H-benzo-2-pyran-1-one (22115-36-2) + methyl 2-(2-oxo-2-phenylacetyl)benzoate (92965-01-0)

Guidance literature:

With N-Bromosuccinimide; water; In 1,2-dichloro-ethane; at 80 ℃; Solvent; Reagent/catalyst; regioselective reaction;

DOI:10.1002/adsc.201700168

upstream raw materials:

3-bromo-2-phenyl-1H-inden-1-one

methyl 2-(phenylethynyl)benzoate

isopropyl 2-(2-phenylethynyl)benzoate

phenindione

Downstream raw materials:

3-phenyl-isocoumarin