2-(3-Chlorophenoxymethyl)oxirane

Base Information

• Chemical Name: 2-(3-Chlorophenoxymethyl)oxirane
• CAS No.: 2211-95-2
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.622
• European Community (EC) Number: 830-929-4
• Mol file: 2211-95-2.mol

Synonyms:2-(3-CHLOROPHENOXYMETHYL)OXIRANE;2211-95-2;2-[(3-chlorophenoxy)methyl]oxirane;3-chlorophenyl glycidyl ether;SCHEMBL5513197;[(3-chlorophenoxy)methyl]oxirane;QMWAQHTYWDAKBC-UHFFFAOYSA-N;AKOS000122884;AKOS017283088;SB45698;SB46060;EN300-22423;Z147642766

Chemical Property of 2-(3-Chlorophenoxymethyl)oxirane

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 184.0291072
• Heavy Atom Count: 12
• Complexity: 152

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(O1)COC2=CC(=CC=C2)Cl

Technology Process of 2-(3-Chlorophenoxymethyl)oxirane

There total 4 articles about 2-(3-Chlorophenoxymethyl)oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(allyloxy)-3-chlorobenzene (24824-86-0) → 1-(3-chlorophenoxy)-2,3,epoxypropane (2211-95-2,114144-44-4,129098-53-9,129098-54-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 18h;

DOI:10.1016/j.ejmech.2017.12.014

Reference yield: 80.0%

3-monochlorophenol (108-43-0) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1-(3-chlorophenoxy)-2,3,epoxypropane (2211-95-2,114144-44-4,129098-53-9,129098-54-0)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide;

DOI:10.1039/c39870001226

Reference yield:

3-monochlorophenol (108-43-0) → 1-(3-chlorophenoxy)-2,3,epoxypropane (2211-95-2,114144-44-4,129098-53-9,129098-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2017.12.014

upstream raw materials:

3-monochlorophenol

epichlorohydrin

1-(allyloxy)-3-chlorobenzene

Downstream raw materials:

4-{2-[3-(3-Chloro-phenoxy)-2-hydroxy-propylamino]-ethoxy}-benzamide

1-azido-3-(3-chlorophenoxy)-2-propanol

(S)-2-(3-chlorophenoxymethyl)oxirane

(S)-2-(3-chloro-phenoxymethyl)-oxirane