Ethyl 2-cyano-2-quinolin-2-ylacetate

Base Information

Chemical Name:Ethyl 2-cyano-2-quinolin-2-ylacetate
CAS No.:22190-15-4
Molecular Formula:C14H12N2O2
Molecular Weight:240.261
Hs Code.:
European Community (EC) Number:683-786-3
DSSTox Substance ID:DTXSID60399846
Mol file:22190-15-4.mol

Synonyms:22190-15-4;Ethyl 2-cyano-2-(quinolin-2-yl)acetate;ethyl 2-cyano-2-quinolin-2-ylacetate;CYANO-QUINOLIN-2-YL-ACETIC ACID ETHYL ESTER;ethyl cyano(2-quinolinyl)acetate;DTXSID60399846;AKOS022660981

Suppliers and Price of Ethyl 2-cyano-2-quinolin-2-ylacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
CYANO-QUINOLIN-2-YL-ACETIC ACID ETHYL ESTER Aldrich
10mg
$ 57.00

Total 1 raw suppliers

Chemical Property of Ethyl 2-cyano-2-quinolin-2-ylacetate

Chemical Property:

Melting Point:165-166 °C
Boiling Point:393.6±27.0 °C(Predicted)
PSA：62.98000
Density:1?+-.0.06 g/cm3(Predicted)
LogP:2.40508
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:240.089877630
Heavy Atom Count:18
Complexity:347

Purity/Quality:: CYANO-QUINOLIN-2-YL-ACETIC ACID ETHYL ESTER Aldrich ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C#N)C1=NC2=CC=CC=C2C=C1

Technology Process of Ethyl 2-cyano-2-quinolin-2-ylacetate

There total 2 articles about Ethyl 2-cyano-2-quinolin-2-ylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.6%

: 1613-37-2
Quinoline N-oxide

: 58734-93-3
Cyano-phenylsulfanyl-acetic acid ethyl ester

: 22190-15-4
ethyl α-cyano-2-quinolineacetate

: 79296-17-6
Cyano-bis-phenylsulfanyl-acetic acid ethyl ester

Guidance literature:: With acetic anhydride; In N,N-dimethyl-formamide; for 12h; Ambient temperature;

Reference yield:

: 2637-38-9
2-quinolyl thiocyanate

: 105-56-6
ethyl 2-cyanoacetate

: 2889-13-6
bis(2-quinolinyl)disulfide

: 2637-37-8
Quinoline-2-thiol

: 22190-15-4
ethyl α-cyano-2-quinolineacetate

Guidance literature:: With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) HMPA, 30 min, 2.) HMPA, RT, 2 h;
DOI:10.1248/cpb.40.1090