5-Oxo Pitavastatin

Base Information

• Chemical Name: 5-Oxo Pitavastatin
• CAS No.: 222306-15-2
• Molecular Formula: C25H22FNO4
• Molecular Weight: 419.44500
• Mol file: 222306-15-2.mol

Synonyms:

Chemical Property of 5-Oxo Pitavastatin

Chemical Property:

• Melting Point: 101-106°C
• Boiling Point: 655.1±55.0 °C(Predicted)
• PKA: 4.18±0.10(Predicted)
• PSA: 87.49000
• Density: 1.349±0.06 g/cm3(Predicted)
• LogP: 4.72630
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

5-Oxo Pitavastatin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-Oxo Pitavastatin is a metabolite of Pitavastatin, a competitive inhibitor of HMG-CoA reductase and is a known antilipemic agent.

Technology Process of 5-Oxo Pitavastatin

There total 3 articles about 5-Oxo Pitavastatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.7%

calcium pitavastatin → C25H22FNO4 (222306-15-2)

Guidance literature:

With manganese(IV) oxide; In N,N-dimethyl-formamide; at 100 ℃; for 4h; Temperature; Solvent;

Reference yield: 0.14%

pitavastatin calcium salt (147526-32-7) → (3R,5S)-5-[(8S)-6-cyclopropyl-7,8-dihydro-10-fluorobenzo[k]phenanthridin-8-yl]-3,5-dihydroxypentanoic acid + (3R,5S)-5-[(8R)-6-cyclopropyl-7,8-dihydro-10-fluorobenzo[k]phenanthridin-8-yl]-3,5-dihydroxypentanoic acid + (3R,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3-hydroxy-5-oxo-6-heptenoic acid (222306-15-2)

Guidance literature:

With titanium(IV) oxide; sodium (E)-6-hydroxy-5-(4-sulfonatophenyl)diazenylnaphthalene-2-sulfonate; In water; Reactivity; Irradiation;

Reference yield:

4R,6S-(E)-6-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylethenyl]-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one → (3R,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3-hydroxy-5-oxo-6-heptenoic acid (222306-15-2)

Guidance literature:

With recombinant microsomes expressing human CYP₃A₄; NADP; glucose 6-phosphate dehydrogenase; magnesium chloride; In water; at 37 ℃; for 0.5h; pH=7.4; Further Variations:; Reagents; reaction times; Product distribution;

DOI:10.1080/0049825021000017957

upstream raw materials:

pitavastatin calcium salt