Technology Process of 2H-Indol-2-one, 1,3-dihydro-3-(3-methyl-2-butenyl)-1-(phenylmethyl)-
There total 4 articles about 2H-Indol-2-one, 1,3-dihydro-3-(3-methyl-2-butenyl)-1-(phenylmethyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-benzylindolin-2-one;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at -78 ℃;
for 1h;
Inert atmosphere;
prenyl bromide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at -78 ℃;
for 1h;
Inert atmosphere;
DOI:10.1002/chem.201002569
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrazine / 140 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 1 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 °C / Inert atmosphere
With
lithium hexamethyldisilazane; hydrazine;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1002/chem.201002569
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / Inert atmosphere
2.1: hydrazine / 140 °C / Inert atmosphere
3.1: lithium hexamethyldisilazane / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 1 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 °C / Inert atmosphere
With
sodium hydride; lithium hexamethyldisilazane; hydrazine;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;
DOI:10.1002/chem.201002569
