Benzene, 4-(2-(3,5-dimethoxyphenyl)ethyl)-1,2-dimethoxy-

Base Information

• Chemical Name: Benzene, 4-(2-(3,5-dimethoxyphenyl)ethyl)-1,2-dimethoxy-
• CAS No.: 22318-87-2
• Molecular Formula: C18H22O4
• Molecular Weight: 302.37
• ChEMBL ID: CHEMBL519743
• DSSTox Substance ID: DTXSID70176862
• Metabolomics Workbench ID: 141874
• Nikkaji Number: J2.219.743F
• Wikidata: Q83047191
• Mol file: 22318-87-2.mol

Synonyms:Gigantol tetramethyl ether;22318-87-2;Benzene, 4-(2-(3,5-dimethoxyphenyl)ethyl)-1,2-dimethoxy-;Bibenzyl, 3,3',4,5'-tetramethoxy-;3,3',4',5-Tetramethoxybibenzyl;CHEMBL519743;DTXSID70176862;combretastsatin B-4 permethyl ether

Chemical Property of Benzene, 4-(2-(3,5-dimethoxyphenyl)ethyl)-1,2-dimethoxy-

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 302.15180918
• Heavy Atom Count: 22
• Complexity: 298

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)CCC2=CC(=CC(=C2)OC)OC)OC

Technology Process of Benzene, 4-(2-(3,5-dimethoxyphenyl)ethyl)-1,2-dimethoxy-

There total 12 articles about Benzene, 4-(2-(3,5-dimethoxyphenyl)ethyl)-1,2-dimethoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

cis-trans-3,3',4',5-tetramethoxystilbene (20767-18-4) → 3,5,4',5'-tetramethoxydihydrostilbene (22318-87-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate;

DOI:10.1021/acs.jnatprod.7b00129

Reference yield: 91.0%

(3,5-dimethoxybenzyl)triphenylphosphonium bromide (24131-30-4) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 3,5,4',5'-tetramethoxydihydrostilbene (22318-87-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 14h;

DOI:10.1021/acs.jnatprod.7b00129

Reference yield: 90.0%

(E)-tetramethylpiceatannol (83088-26-0) → 3,5,4',5'-tetramethoxydihydrostilbene (22318-87-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

upstream raw materials:

diazomethane

gigantol

cis-trans-3,3',4',5-tetramethoxystilbene

(E)-tetramethylpiceatannol

Downstream raw materials:

Dihydropiceatannol

3,4,3',5'-Tetramethoxy-2',6'-diioddibenzyl