Chemical Property of N-[(1-Chloro-4-hydroxyisoquinolin-3-YL)carbonyl]glycine
Chemical Property:
- Boiling Point:670.6±55.0 °C(Predicted)
- PKA:3.20±0.10(Predicted)
- PSA：99.52000
- Density:1.571±0.06 g/cm3(Predicted)
- LogP:1.79910
- Storage Temp.:-20°C
- Solubility.:insoluble in H2O; ≥14.05 mg/mL in DMSO; ≥5.12 mg/mL in EtOH with ultrasonic
- XLogP3:2.5
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:3
- Exact Mass:280.0250845
- Heavy Atom Count:19
- Complexity:366
- Purity/Quality:
-
99%, *data from raw suppliers
FG 2216 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC=C2C(=C1)C(=C(N=C2Cl)C(=O)NCC(=O)O)O
- Recent ClinicalTrials:A Randomized Study of the Safety and Efficacy of FG-2216 in Subjects With Renal Anemia Not Requiring Dialysis and Not Receiving Recombinant Human Erythropoietin
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Description
FG-2216 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC50 = 3.9 micromolar). It has been shown to reversibly stimulate erythropoietin secretion at 100 μM in vitro and to increase hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.
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Uses
FG 2216 is an erythropoietic agent which is orally active prolyl-hydroxylase inhibitor which increases erythropoietin production in end-stage kidney disease.
