5,8,14-Trioxa-2,11-diazahexadecanedioic acid, 12-oxo-, 1-(1,1-dimethylethyl) ester

Base Information

• Chemical Name: 5,8,14-Trioxa-2,11-diazahexadecanedioic acid, 12-oxo-, 1-(1,1-dimethylethyl) ester
• CAS No.: 223599-67-5
• Molecular Formula: C15H28N2O8
• Molecular Weight: 364.39100
• Mol file: 223599-67-5.mol

Synonyms:({2-[2-(2-tert-Butoxycarbonylamino-ethoxy)-ethoxy]-ethylcarbamoyl}-methoxy)-acetic acid;

Chemical Property of 5,8,14-Trioxa-2,11-diazahexadecanedioic acid, 12-oxo-, 1-(1,1-dimethylethyl) ester

Chemical Property:

• Boiling Point: 596.5±50.0 °C(Predicted)
• PSA: 132.42000
• Density: 1.182±0.06 g/cm3(Predicted)
• LogP: 0.54350

Purity/Quality:

BocNH-PEG2-CH2CH2NHCOCH2OCH2COOH 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,8,14-Trioxa-2,11-diazahexadecanedioic acid, 12-oxo-, 1-(1,1-dimethylethyl) ester

There total 3 articles about 5,8,14-Trioxa-2,11-diazahexadecanedioic acid, 12-oxo-, 1-(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,4-dioxane-2,6-dione (4480-83-5) + tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate (153086-78-3) → 14-(tert-butoxycarbonylamino)-5-oxo-3,9,12-trioxa-6-azatetradecan-1-oic acid (223599-67-5)

Guidance literature:

With pyridine; In 1,4-dioxane; at 90 ℃; for 4h;

DOI:10.1016/S0960-894X(98)00697-0

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 14-(tert-butoxycarbonylamino)-5-oxo-3,9,12-trioxa-6-azatetradecan-1-oic acid (223599-67-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dioxane / 2 h / 20 °C

2: 1.5 g / 4,4'-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / 20 °C

With dmap; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm030369+

Reference yield:

3,6-dioxa-1,8-diaminooctane (929-59-9,892154-56-2) → 14-(tert-butoxycarbonylamino)-5-oxo-3,9,12-trioxa-6-azatetradecan-1-oic acid (223599-67-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dioxane / 2 h / 20 °C

2: 1.5 g / 4,4'-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / 20 °C

With dmap; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm030369+

upstream raw materials:

1,4-dioxane-2,6-dione

tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate

3,6-dioxa-1,8-diaminooctane

di-tert-butyl dicarbonate

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