2-(trifluoroMethyl)cyclopropanecarboxylic acid

Base Information

• Chemical Name: 2-(trifluoroMethyl)cyclopropanecarboxylic acid
• CAS No.: 22581-33-5
• Molecular Formula: C5H5F3O2
• Molecular Weight: 154.089
• Hs Code.: 2916209090
• Mol file: 22581-33-5.mol

Synonyms:trans-2-trifluoromethylcyclopropanecarboxylic acid;E-2-Tridecen-1-ol;trans-2-tridecenol;

Chemical Property of 2-(trifluoroMethyl)cyclopropanecarboxylic acid

Chemical Property:

• Boiling Point: 168.1±35.0 °C(Predicted)
• PKA: 3.95±0.11(Predicted)
• PSA: 37.30000
• Density: 1.563±0.06 g/cm3(Predicted)
• LogP: 1.26940

Purity/Quality:

99%, ^*data from raw suppliers

2-(Trifluoromethyl)cyclopropanecarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(trifluoroMethyl)cyclopropanecarboxylic acid

There total 14 articles about 2-(trifluoroMethyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-methoxy-N-methyl-2-(trifluoromethyl)cyclopropanecarboxamide → (±)-trans-2-(trifluoromethyl)cyclopropane-1-carboxylic acid (22581-33-5,78376-99-5)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; water; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1055/s-0031-1289711

Reference yield: 65.0%

ethyl 5,5,5-trifluoro-4-tosyloxyvalerate (94633-26-8) → (±)-trans-2-(trifluoromethyl)cyclopropane-1-carboxylic acid (22581-33-5,78376-99-5)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide;

Reference yield: 56.0%

((E)-2-((1RS,2SR)-2-(trifluoromethyl)cyclopropyl)vinyl)benzene → (±)-trans-2-(trifluoromethyl)cyclopropane-1-carboxylic acid (22581-33-5,78376-99-5)

Guidance literature:

With sodium periodate; ruthenium(III) trichloride hydrate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 2h;

DOI:10.1021/ol200983s

upstream raw materials:

5,5,5-Trifluor-4-(p-toluolsulfonyloxy)-valeriansaeure-methylester

5,5,5-trifluoro-4-oxopentanoic acid

methyl 5,5,5-trifluoro-4-hydroxypentanoate

methyl 5,5,5-trifluoro-4-oxopentanoate

Downstream raw materials:

trans-2-trifluoromethylcyclopropylmethanol

Toluene-4-sulfonic acid (1R,2R)-2-trifluoromethyl-cyclopropylmethyl ester