(4-Bromo-3-fluorophenyl)hydrazine

Base Information

• Chemical Name: (4-Bromo-3-fluorophenyl)hydrazine
• CAS No.: 227015-68-1
• Molecular Formula: C6H6BrFN2
• Molecular Weight: 205.02800
• European Community (EC) Number: 820-769-3
• DSSTox Substance ID: DTXSID90478592
• Wikidata: Q82312076
• Mol file: 227015-68-1.mol

Synonyms:(4-Bromo-3-fluorophenyl)hydrazine;227015-68-1;4-Bromo-3-fluorophenylhydrazine;Hydrazine, (4-bromo-3-fluorophenyl)-;SCHEMBL1874984;AMY4974;DTXSID90478592;LEMDELXPDAYDKA-UHFFFAOYSA-N;CJA01568;MFCD12025321;(4-bromo-3-fluoro-phenyl)-hydrazine;AKOS014771759;GS-6053;SB77861;CS-0100351;EN300-140752;H10006

Chemical Property of (4-Bromo-3-fluorophenyl)hydrazine

Chemical Property:

• Boiling Point: 263.2±30.0 °C(Predicted)
• PKA: 4.80±0.24(Predicted)
• PSA: 38.05000
• Density: 1.760±0.06 g/cm3(Predicted)
• LogP: 2.64710
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 203.96984
• Heavy Atom Count: 10
• Complexity: 112

Purity/Quality:

99% ^*data from raw suppliers

(4-Bromo-3-Fluorophenyl)Hydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1NN)F)Br

Technology Process of (4-Bromo-3-fluorophenyl)hydrazine

There total 1 articles about (4-Bromo-3-fluorophenyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-fluoro-4-bromophenylamine (656-65-5) → (4-bromo-3-fluorophenyl)-hydrazine (227015-68-1)

Guidance literature:

Reference yield: 29.0%

p-acetylaminobenzenesulfonyl chloride (121-60-8) + (4-bromo-3-fluorophenyl)-hydrazine (227015-68-1) → N-(4-{[2-(4-bromo-3-fluorophenyl)hydrazinyl]sulfonyl}phenyl)acetamide (1620001-52-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2014.05.084

Reference yield:

(4-bromo-3-fluorophenyl)-hydrazine (227015-68-1) → C30H25FN6O3

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 18 h / 0 - 20 °C / Sealed tube

2: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium phosphate / water; 1,4-dioxane / 1.5 h / 90 °C / Inert atmosphere

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 50 °C

With potassium phosphate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); lithium hydroxide monohydrate; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

upstream raw materials:

3-fluoro-4-bromophenylamine

Downstream raw materials:

N-(4-{[2-(4-bromo-3-fluorophenyl)hydrazinyl]sulfonyl}phenyl)acetamide