7-Azabicyclo[2.2.1]hepta-2,5-diene-7-carboxylic acid, 2-bromo-3-[(4-methylphenyl)sulfonyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:7-Azabicyclo[2.2.1]hepta-2,5-diene-7-carboxylic acid, 2-bromo-3-[(4-methylphenyl)sulfonyl]-, 1,1-dimethylethyl ester
CAS No.:227454-53-7
Molecular Formula:C₁₈H₂₀BrNO₄S
Molecular Weight:426.331
Hs Code.:
Mol file:227454-53-7.mol

Synonyms:

Suppliers and Price of 7-Azabicyclo[2.2.1]hepta-2,5-diene-7-carboxylic acid, 2-bromo-3-[(4-methylphenyl)sulfonyl]-, 1,1-dimethylethyl ester

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Chemical Property of 7-Azabicyclo[2.2.1]hepta-2,5-diene-7-carboxylic acid, 2-bromo-3-[(4-methylphenyl)sulfonyl]-, 1,1-dimethylethyl ester

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Technology Process of 7-Azabicyclo[2.2.1]hepta-2,5-diene-7-carboxylic acid, 2-bromo-3-[(4-methylphenyl)sulfonyl]-, 1,1-dimethylethyl ester

There total 2 articles about 7-Azabicyclo[2.2.1]hepta-2,5-diene-7-carboxylic acid, 2-bromo-3-[(4-methylphenyl)sulfonyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13894-21-8
ethynyl p-tolyl sulfone

: 227454-53-7
2-bromo-3-(toluene-4-sulfonyl)-7-aza-bicyclo[2.2.1]hepta-2,5-diene-7-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / NBS, AgNO₃ / acetone / 0.5 h

2: 78 percent / toluene / 24 h / 90 °C

With N-Bromosuccinimide; silver nitrate; In acetone; toluene;
DOI:10.1039/a900970a

Reference yield:

: 34452-56-7
trimethylsilyl p-tolylsulfonylacetylene

: 227454-53-7
2-bromo-3-(toluene-4-sulfonyl)-7-aza-bicyclo[2.2.1]hepta-2,5-diene-7-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NBS, AgNO₃ / acetone / 0.5 h / Ambient temperature

2: 78 percent / toluene / 24 h / 90 °C

With N-Bromosuccinimide; silver nitrate; In acetone; toluene;
DOI:10.1039/a900970a

Reference yield:

: 227454-53-7
2-bromo-3-(toluene-4-sulfonyl)-7-aza-bicyclo[2.2.1]hepta-2,5-diene-7-carboxylic acid tert-butyl ester

: 227454-55-9
2-oxo-3-(toluene-4-sulfonyl)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Et₂NH, Et₃N_. 2.) HCl, H₂O / 1.) CH₃CN, r.t., 2.) r.t.

2: H₂ / 10 percent Pd/C / methanol

With hydrogenchloride; water; hydrogen; diethylamine; triethylamine; palladium on activated charcoal; In methanol;
DOI:10.1039/a900970a