Benzenamine, 4-methyl-N-2-propynyl-

Base Information

• Chemical Name: Benzenamine, 4-methyl-N-2-propynyl-
• CAS No.: 22774-64-7
• Molecular Formula: C10H11N
• Molecular Weight: 145.204
• Mol file: 22774-64-7.mol

Synonyms:4-methyl-N-(prop-2-ynyl)benzenamine;N-(2-propynyl)-p-toluidine;3-(4-methylanilino)propyne;4-methyl-N-propargylaniline;4-methyl-N-(prop-2-ynyl)aniline;N-propargyl-N-p-tolylamine;Prop-2-ynyl-p-tolyl-amine;

Chemical Property of Benzenamine, 4-methyl-N-2-propynyl-

Chemical Property:

• Boiling Point: 99 - 100 °C (0.3 mmHg)
• PSA: 12.03000
• LogP: 2.11310

Purity/Quality:

99% ^*data from raw suppliers

AS008961:Prop-2-ynyl-p-tolyl-amine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenamine, 4-methyl-N-2-propynyl-

There total 19 articles about Benzenamine, 4-methyl-N-2-propynyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

p-toluidine (106-49-0,12221-03-3) + propargyl bromide (106-96-7) → N-propargyl-4-methylaniline (22774-64-7)

Guidance literature:

p-toluidine; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

propargyl bromide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 88.0%

4-methylphenylboronic acid (5720-05-8) + 2-propynyl chloride (624-65-7) → N-propargyl-4-methylaniline (22774-64-7)

Guidance literature:

With copper(I) oxide; ammonium hydroxide; potassium carbonate; In water; for 0.166667h; Microwave irradiation;

DOI:10.1055/s-0033-1340331

Reference yield: 85.0%

4-methylphenylboronic acid (5720-05-8) + propargyl bromide (106-96-7) → N-propargyl-4-methylaniline (22774-64-7)

Guidance literature:

With copper(I) oxide; ammonium hydroxide; potassium carbonate; In water; for 0.166667h; Solvent; Reagent/catalyst; Microwave irradiation;

DOI:10.1055/s-0033-1340331

upstream raw materials:

p-toluidine

propargyl bromide

propargyl benzenesulfonate

propargyl p-toluenesulfonate

Downstream raw materials:

1-methyl-4-<3-(4-methylanilino)-1-propynyl>-4-piperidol

2,5-dihydro-1-(4-methylphenyl)-1H-pyrrole

6-methylquinoline

9-[4-(p-tolylamino-methyl)-[1,2,3]triazol-1-yl]-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one