2-[[3-[(2-Hydroxyphenyl)methylamino]propylamino]methyl]phenol

Base Information

• Chemical Name: 2-[[3-[(2-Hydroxyphenyl)methylamino]propylamino]methyl]phenol
• CAS No.: 2287-28-7
• Molecular Formula: C17H22N2O2
• Molecular Weight: 286.374
• DSSTox Substance ID: DTXSID70367738
• Nikkaji Number: J1.063.167J
• Wikidata: Q82153780
• Pharos Ligand ID: PRXR9P9XY9NW
• ChEMBL ID: CHEMBL1467754
• Mol file: 2287-28-7.mol

Synonyms:CHEMBL1467754;2-[[3-[(2-hydroxyphenyl)methylamino]propylamino]methyl]phenol;MLS000062749;2287-28-7;Phenol, 2,2'-[1,3-propanediylbis(iminomethylene)]bis-;SCHEMBL11241212;DTXSID70367738;N,N'-Disalicyltrimethylenediamine;REGID_for_CID_2283723;HMS2364I21;BDBM50494682;SMR000071286;N,N'-bis-(2-hydroxy-benzyl) 1,3-diaminopropane;2,2'-[1,3-propanediylbis(iminomethylene)]diphenol

Chemical Property of 2-[[3-[(2-Hydroxyphenyl)methylamino]propylamino]methyl]phenol

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 286.168127949
• Heavy Atom Count: 21
• Complexity: 250

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CNCCCNCC2=CC=CC=C2O)O

Technology Process of 2-[[3-[(2-Hydroxyphenyl)methylamino]propylamino]methyl]phenol

There total 8 articles about 2-[[3-[(2-Hydroxyphenyl)methylamino]propylamino]methyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N,N'-propane-1,3-diylbis(salicylideneimine) (120-70-7) → N,N'-bis(2-hydroxybenzyl)-1,3-diaminopropane (2287-28-7)

Guidance literature:

With sodium tetrahydroborate; In methanol;

DOI:10.1002/ejic.201100489

Reference yield: 84.16%

2-bis{[(1E)-(2-hydroxyphenyl)methylene]amino}propane (133345-53-6) → N,N'-bis(2-hydroxybenzyl)-1,3-diaminopropane (2287-28-7)

Guidance literature:

With sodium hydroxide; sodium tetrahydroborate; In methanol; at 20 ℃; for 8h;

Reference yield: 80.0%

salicylaldehyde (90-02-8) + Trimethylenediamine (109-76-2,54018-94-9) → N,N'-bis(2-hydroxybenzyl)-1,3-diaminopropane (2287-28-7)

Guidance literature:

salicylaldehyde; Trimethylenediamine; In methanol; for 2h; Reflux;

With sodium tetrahydroborate; for 0.5h; Reflux;

DOI:10.1016/j.inoche.2018.12.009

upstream raw materials:

N,N'-propane-1,3-diylbis(salicylideneimine)

2-bis{[(1E)-(2-hydroxyphenyl)methylene]amino}propane

2-methyl-benzyl alcohol

salicylaldehyde

Downstream raw materials:

C₂₃H₂₅N₃O₂

C₂₃H₂₅N₃O₂

C₂₆H₂₈N₂O₂

bis-2,2′-[(dihydro-1,3(2H,4H)-pyrimidinediyl)bis(methylene)]phenol