N-(3,5-di-tert-butyl-4-hydroxyphenyl)acetamide

Base Information

Chemical Name:N-(3,5-di-tert-butyl-4-hydroxyphenyl)acetamide
CAS No.:22903-23-7
Molecular Formula:C16H25NO2
Molecular Weight:263.38
Hs Code.:
DSSTox Substance ID:DTXSID90358289
Nikkaji Number:J1.002.314I
Wikidata:Q82138754
ChEMBL ID:CHEMBL116879
Mol file:22903-23-7.mol

Synonyms:N-(3,5-di-tert-butyl-4-hydroxyphenyl)acetamide;22903-23-7;Oprea1_391302;MLS000530703;3,5-Di-tert-butylparacetamol;CHEMBL116879;SCHEMBL2276660;DTXSID90358289;Acetamide, N-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-;HMS2401L11;STK832900;AKOS002783751;SMR000135681;SR-01000238725;SR-01000238725-1

Suppliers and Price of N-(3,5-di-tert-butyl-4-hydroxyphenyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-(3,5-di-tert-butyl-4-hydroxyphenyl)acetamide

Chemical Property:

PSA：52.82000
LogP:4.59510
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:263.188529040
Heavy Atom Count:19
Complexity:301

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C

Technology Process of N-(3,5-di-tert-butyl-4-hydroxyphenyl)acetamide

There total 4 articles about N-(3,5-di-tert-butyl-4-hydroxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 108-24-7
acetic anhydride

: 101213-98-3
N,N'-thiobis(2,6-di-t-butyl-1,4-benzoquinone imine)

: 22903-23-7
N-(3,5-di-tert-butyl-4-hydroxyphenyl)-acetamide

Guidance literature:: With acetic acid; zinc; for 0.0833333h; Heating;

Reference yield:

: 950-58-3
2,6-di-tert-butyl-4-aminophenol

: 108-24-7
acetic anhydride

: 22903-23-7
N-(3,5-di-tert-butyl-4-hydroxyphenyl)-acetamide

Guidance literature:: In methanol; at 20 ℃; for 0.5h;
DOI:10.1016/j.tet.2012.09.098

Reference yield:

: 128-39-2
2,6-di-tert-butylphenol

: 22903-23-7
N-(3,5-di-tert-butyl-4-hydroxyphenyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; 4-aminobenzene sulfonic acid; sodium carbonate; sodium nitrite; hydrogenchloride / water / 1 h / 0 °C

1.2: 80 °C

2.1: methanol / 0.5 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium carbonate; sodium nitrite; 4-aminobenzene sulfonic acid; In methanol; water;
DOI:10.1016/j.tet.2012.09.098