Olivetol Dimethyl Ether

Base Information

• Chemical Name: Olivetol Dimethyl Ether
• CAS No.: 22976-40-5
• Molecular Formula: C13H20O2
• Molecular Weight: 208.301
• Hs Code.: 2909309090
• Mol file: 22976-40-5.mol

Synonyms:bis methyl ether of olivetol;Olivetol Dimethyl Ether;1,3-Dimethoxy-5-pentyl-benzol;dimethoxyolivetol;3,5-Dimethoxyamylbenzene;Olivetol,O,O-dimethyl;1,3-dimethoxy-5-pentyl-benzene;Benzene,1,3-dimethoxy-5-pentyl;Di-O-methylolivetol;

Chemical Property of Olivetol Dimethyl Ether

Chemical Property:

• Boiling Point: 130 °C
• PSA: 18.46000
• Density: 0.978 g/cm3(Temp: 25 °C)
• LogP: 3.43650
• Solubility.: Dichloromethane, Ethyl Acetate

Purity/Quality:

97% ^*data from raw suppliers

OlivetolDimethylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate in various syntheses of tetrahydrocannabinol. Olivetol Dimethyl Ether is an intermediate in various syntheses of tetrahydrocannabinol.

Technology Process of Olivetol Dimethyl Ether

There total 72 articles about Olivetol Dimethyl Ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,3-dimethoxy-5-(pent-1-yn-1-yl)benzene → 1,3-dimethoxy-5-pentylbenzene (22976-40-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 3750.38 Torr;

DOI:10.1016/j.tet.2017.07.029

Reference yield: 98.0%

dimethyl sulfate (77-78-1) + Olivetol (500-66-3) → 1,3-dimethoxy-5-pentylbenzene (22976-40-5)

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃; for 4h;

DOI:10.1021/ol063022k

Reference yield: 98.0%

1,3-dimethoxy-5-(pent-1-en-1-yl)benzene (38228-29-4) → 1,3-dimethoxy-5-pentylbenzene (22976-40-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; for 24h; under 1485.65 Torr;

DOI:10.1021/acs.jmedchem.1c00561

upstream raw materials:

toluene-4-sulfonic acid

benzene

2-(3,5-dimethoxy-benzyl)-thiophene

1-(3,5-Dimethoxyphenyl)-2-methylsulfonyl-pentan-3-on

Downstream raw materials:

primine

2,6-dimethoxy-4-pentylbenzaldehyde

2,4-dibromo-1,5-dimethoxy-3-pentylbenzene

Olivetol

Refernces

• 1、 Novak,Salemink. "A new and efficient synthesis of 5-alkylresorcinol dimethyl ethers". . p. 597 - 598. Retrieved 1983.
• 2、 -. "CANNABIGEROL DERIVATIVES AND USE THEREOF AS CANNABINOID RECEPTOR MODULATORS". Paragraph 0128. . Retrieved 2021/06/04.
• 3、 -. "Preparation method of 3,5-dihydroxyamylbenzene". . . Retrieved 2021/06/12.