Benzamide, 4-amino-N-(2-(3,4,6,7,12,12a-hexahydropyrazino(1',2':1,6)pyrido(3,4-b)indol-2(1H)-yl)ethyl)-

Base Information

Chemical Name:Benzamide, 4-amino-N-(2-(3,4,6,7,12,12a-hexahydropyrazino(1',2':1,6)pyrido(3,4-b)indol-2(1H)-yl)ethyl)-
CAS No.:72593-33-0
Molecular Formula:C23H27 N5 O
Molecular Weight:389.4934
Hs Code.:
DSSTox Substance ID:DTXSID80993446

Synonyms:BRN 4585394;72593-33-0;Benzamide, 4-amino-N-(2-(3,4,6,7,12,12a-hexahydropyrazino(1',2':1,6)pyrido(3,4-b)indol-2(1H)-yl)ethyl)-;C23H27N5O;DTXSID80993446;C23-H27-N5-O;LS-25548;4-Amino-N-[2-(3,4,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-2(1H)-yl)ethyl]benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzamide, 4-amino-N-(2-(3,4,6,7,12,12a-hexahydropyrazino(1',2':1,6)pyrido(3,4-b)indol-2(1H)-yl)ethyl)-

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:389.22156050
Heavy Atom Count:29
Complexity:578

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN2CC3=C(CC2CN1CCNC(=O)C4=CC=C(C=C4)N)C5=CC=CC=C5N3

Technology Process of Benzamide, 4-amino-N-(2-(3,4,6,7,12,12a-hexahydropyrazino(1',2':1,6)pyrido(3,4-b)indol-2(1H)-yl)ethyl)-

There total 4 articles about Benzamide, 4-amino-N-(2-(3,4,6,7,12,12a-hexahydropyrazino(1',2':1,6)pyrido(3,4-b)indol-2(1H)-yl)ethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.2%

: 72593-22-7,72593-30-7,75144-38-6
2-β-(4'-Nitrobenzoyl)aminoethyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole

: 72593-33-0
2-β-(4'-Aminobenzoyl)aminoethyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole

Guidance literature:: With hydrogen; nickel; In ethanol; for 10h; under 2327.2 Torr;

Reference yield:

: 91119-30-1
2-Cyanomethyl 1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indol

: 72593-33-0
2-β-(4'-Aminobenzoyl)aminoethyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole

Guidance literature:: Multi-step reaction with 3 steps

1: 78.6 percent / LAH / tetrahydrofuran / 10 h / Heating

2: 72.9 percent / Et₃N / tetrahydrofuran / 1) 1h, 30 deg C, 2) 5h, reflux

3: 83.2 percent / H₂ / Raney-Ni / ethanol / 10 h / 2327.2 Torr

With lithium aluminium tetrahydride; hydrogen; triethylamine; nickel; In tetrahydrofuran; ethanol;

Reference yield:

: 91119-31-2
2-β-Aminoethyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole

: 72593-33-0
2-β-(4'-Aminobenzoyl)aminoethyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole

Guidance literature:: Multi-step reaction with 2 steps

1: 72.9 percent / Et₃N / tetrahydrofuran / 1) 1h, 30 deg C, 2) 5h, reflux

2: 83.2 percent / H₂ / Raney-Ni / ethanol / 10 h / 2327.2 Torr

With hydrogen; triethylamine; nickel; In tetrahydrofuran; ethanol;