2,3,5-Trimethoxybromobenzene

Base Information

• Chemical Name: 2,3,5-Trimethoxybromobenzene
• CAS No.: 23030-39-9
• Molecular Formula: C9H11BrO3
• Molecular Weight: 247.089
• Mol file: 23030-39-9.mol

Synonyms:1-bromo-2,3,5-trimethoxy-benzene;2,3,5-trimethoxybromobenzene;1,3,4-Trimethoxy-5-brom-benzol;bromo-2,3,5-trimethoxybenzene;1-Brom-2,3,5-trimethoxy-benzol;

Chemical Property of 2,3,5-Trimethoxybromobenzene

Chemical Property:

• Boiling Point: 170-173 °C(Press: 25 Torr)
• PSA: 27.69000
• Density: 1.391±0.06 g/cm3(Predicted)
• LogP: 2.47490
• Solubility.: DCM; Ethyl Acetate

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3,5-Trimethoxybromobenzene is an intermediate in the synthesis of 2,3,5-Trimethoxyamphetamine (T896885) which is a derivative of Amphetamine (A634240), CNS stimulant; anorexic.Controlled substance (stimulant).

Technology Process of 2,3,5-Trimethoxybromobenzene

There total 7 articles about 2,3,5-Trimethoxybromobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,5-dihydroxy-3-methoxy-1-bromobenzene (61654-67-9) + dimethyl sulfate (77-78-1) → 1-bromo-2,3,5-trimethoxybenzene (23030-39-9)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 18h;

DOI:10.1021/ol902959v

Reference yield: 93.0%

1-bromo-5-hydroxy-2,3-dimethoxybenzene (93092-14-9) + dimethyl sulfate (77-78-1) → 1-bromo-2,3,5-trimethoxybenzene (23030-39-9)

Guidance literature:

With potassium carbonate; In acetone; for 12h; Ambient temperature;

DOI:10.1016/S0040-4020(01)96630-X

Reference yield: 73.0%

→ 1-bromo-2,3,5-trimethoxybenzene (23030-39-9)

Guidance literature:

upstream raw materials:

5-bromo-4-hydroxy-3-methoxybenzaldehyde

2,5-dihydroxy-3-methoxy-1-bromobenzene

dimethyl sulfate

1-bromo-5-hydroxy-2,3-dimethoxybenzene

Downstream raw materials:

2,3,5-trimethoxydiphenyl ether

5-benzyloxy-1,3,4-trimethoxy-9(10H)-acridone

5-benzyloxy-1,3,4-trimethoxy-10-methyl-9(10H)-acridone

Citrusinine-I