3-Quinolinecarbonitrile, 4-hydroxy-7-methoxy-

Base Information

Chemical Name:3-Quinolinecarbonitrile, 4-hydroxy-7-methoxy-
CAS No.:2305-69-3
Molecular Formula:C11H8N2O2
Molecular Weight:200.19300
Hs Code.:2933499090
Mol file:2305-69-3.mol

Synonyms:4-Hydroxy-6-methoxy-3-cyanchinolin;3-Quinolinecarbonitrile,4-hydroxy-6-methoxy;3-Cyan-4-hydroxy-7-methoxychinolin;3-Cyan-4-hydroxy-6-methoxychinolin;4-HYDROXY-6-METHOXYQUINOLINE-3-CARBONITRILE;3-Cyano-4-hydroxy-7-methoxychinolin;

Suppliers and Price of 3-Quinolinecarbonitrile, 4-hydroxy-7-methoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
4-Hydroxy-7-methoxyquinoline-3-carbonitrile 97%
10g
$ 2520.00

Matrix Scientific
4-Hydroxy-7-methoxyquinoline-3-carbonitrile 97%
5g
$ 1620.00

Crysdot
4-hydroxy-7-methoxyquinoline-3-carbonitrile 95+%
1g
$ 386.00

Chemenu
4-hydroxy-7-methoxyquinoline-3-carbonitrile 95%
1g
$ 365.00

Alichem
4-Hydroxy-7-methoxy-3-quinolinecarbonitrile
1g
$ 429.00

Alichem
4-Hydroxy-7-methoxy-3-quinolinecarbonitrile
5g
$ 1405.95

Abosyn
4-hydroxy-7-methoxyquinoline-3-carbonitrile 95%-98%
1g
$ 926.00

Total 10 raw suppliers

Chemical Property of 3-Quinolinecarbonitrile, 4-hydroxy-7-methoxy-

Chemical Property:

Vapor Pressure:3.88E-05mmHg at 25°C
Boiling Point:352.3oC at 760 mmHg
Flash Point:166.8oC
PSA：65.88000
Density:1.32g/cm3
LogP:1.40838

Purity/Quality:

99% ^*data from raw suppliers

4-Hydroxy-7-methoxyquinoline-3-carbonitrile 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Quinolinecarbonitrile, 4-hydroxy-7-methoxy-

There total 2 articles about 3-Quinolinecarbonitrile, 4-hydroxy-7-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 536-90-3,918666-97-4
m-Anisidine

: 94-05-3,42466-69-3
ethyl (ethoxymethylene)cyanoacetate

: 2305-69-3
4-hydroxy-7-methoxyquinoline-3-carbonitrile

Guidance literature:: m-Anisidine; ethyl (ethoxymethylene)cyanoacetate; at 120 ℃; for 0.0833333h; under 9826.07 Torr; Microwave irradiation;

In diphenylether; at 230 ℃; for 0.116667h; under 9308.91 Torr; Microwave irradiation;
DOI:10.1021/acs.jmedchem.5b00108

Reference yield:

: 2305-69-3
4-hydroxy-7-methoxyquinoline-3-carbonitrile

Guidance literature:: m-Anisidin + Ethoxymethylen-cyanessigsaeureethylester, Δ;

Reference yield:

: 2305-69-3
4-hydroxy-7-methoxyquinoline-3-carbonitrile

: 4-((2,4-dichlorophenyl)amino)-7-methoxyquinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 2 h / Inert atmosphere; Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 2 h / Reflux

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.jmedchem.5b00108