Pyrido[1,2-a]pyriMidin-4-one

Base Information

• Chemical Name: Pyrido[1,2-a]pyriMidin-4-one
• CAS No.: 23443-10-9
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.148
• Hs Code.: 2933990090
• Mol file: 23443-10-9.mol

Synonyms:4-oxo-4H-pyridino[1,2-a]pyrimidine;4H-Pyrido[1,2-a]pyrimidin-4-one;pyrido

Chemical Property of Pyrido[1,2-a]pyriMidin-4-one

Chemical Property:

• Melting Point: 127 °C
• Boiling Point: 276.4±23.0 °C(Predicted)
• PKA: 3.20±0.30(Predicted)
• PSA: 34.37000
• Density: 1.24±0.1 g/cm3(Predicted)
• LogP: 0.69450

Purity/Quality:

97% ^*data from raw suppliers

4H-Pyrido[1,2-a]pyrimidin-4-one ^*data from reagent suppliers

Safty Information:

• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrido[1,2-a]pyriMidin-4-one

There total 2 articles about Pyrido[1,2-a]pyriMidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

7-iodopyrido[1,2-a]pyrimidin-4-one (746668-67-7) + phenylboronic acid (98-80-6) → pyrido[1,2-a]pyrimidin-4-one (23443-10-9) + 7-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 4h;

DOI:10.1039/c1ob05505d

Reference yield:

3-iodo-4H-pyrido[1,2-a]pyrimidin-4-one (1198413-28-3) + phenylboronic acid (98-80-6) → pyrido[1,2-a]pyrimidin-4-one (23443-10-9) + 3-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one (25816-51-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 4h;

DOI:10.1039/c1ob05505d

Reference yield: 90.0%

pyrido[1,2-a]pyrimidin-4-one (23443-10-9) + 4-tert-Butylstyrene (1746-23-2,26009-55-2) → (E)-3-(4-tert-butylstyryl)-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:

With oxygen; silver(I) acetate; palladium diacetate; In N,N-dimethyl-formamide; at 110 ℃; for 12h; regioselective reaction;

DOI:10.1002/asia.201402455

upstream raw materials:

7-iodopyrido[1,2-a]pyrimidin-4-one

phenylboronic acid

3-iodo-4H-pyrido[1,2-a]pyrimidin-4-one

Downstream raw materials:

3-(4'-methoxyphenyl)-4H-pyrido[1,2-a]pyrimidin-4-one

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