Hyperforin . DCHA

Base Information

• Chemical Name: Hyperforin . DCHA
• CAS No.: 238074-03-8
• Molecular Formula: C35H52O4.C12H23N
• Molecular Weight: 718.10300
• Mol file: 238074-03-8.mol

Synonyms:hyperforin dicyclohexylammonium salt;Hyp-DCHA Hyperforin-DCHA;Hyp-DCHA;Hyperforin-DCHA;

Chemical Property of Hyperforin . DCHA

Chemical Property:

• PSA: 83.47000
• LogP: 12.62200
• Storage Temp.: ?20°C
• Solubility.: DMSO: ≥10mg/mL

Purity/Quality:

98%,99%, ^*data from raw suppliers

Hyperforin DCHA ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,N
• Statements: 22-34-50/53
• Safety Statements: 26-36/37/39-45-60-61

MSDS Files:

Useful:

• Description: Hyperforin is a natural activator of the steroid X receptor (active at 0.1 to 0.5 μg/ml) and inhibitor of several cytochrome P450 (CYP) isoforms (IC50 = 10 μg/ml for CYP2D6). It can also inhibit microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50 = 1 μM), 5-lipoxygenase activating protein, and sirtuins.

Technology Process of Hyperforin . DCHA

There total 1 articles about Hyperforin . DCHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-cyclohexyl-cyclohexanamine (101-83-7) + hyperforin (11079-53-1) → hyperforin (dicyclohexylammonium) salt (238074-03-8)

Guidance literature:

With pyridine; In hexane; isopropyl alcohol; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1080/10286020.2011.584532

Reference yield: 28.0%

hyperforin (dicyclohexylammonium) salt (238074-03-8) → 8-hydroxyhyperforin 8,1-hemiacetal + furohyperforin (219793-20-1) + pyrano[7,28-b]hyperforin + (1S,3S,5S,6R,7S)-3-Hydroxy-5-isobutyryl-6-methyl-1,3,7-tris-(3-methyl-but-2-enyl)-6-(4-methyl-pent-3-enyl)-bicyclo[3.3.1]nonane-2,4,9-trione

Guidance literature:

With dipyridinium dichromate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/np0105681

upstream raw materials:

N-cyclohexyl-cyclohexanamine

hyperforin

Downstream raw materials:

furohyperforin