Technology Process of Acetamide,
N-[[(5R)-3-[3,5-difluoro-4-(4-morpholinyl)phenyl]-4,5-dihydro-5-isoxazol
yl]methyl]-
There total 6 articles about Acetamide,
N-[[(5R)-3-[3,5-difluoro-4-(4-morpholinyl)phenyl]-4,5-dihydro-5-isoxazol
yl]methyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-allylacetamide; 3,5-difluoro-4-(4-morpholino)-N-hydroxybenzenecarboximidoyl chloride;
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
Further stages.;
chiral HPLC on Chiralpak AD column;
DOI:10.1021/jm020248u
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 88 percent / KH2PO4 / dimethylsulfoxide / 15 h / 75 °C
2.1: LiAlH4 / tetrahydrofuran / 1 h / 0 °C
3.1: 3.27 g / TPAP; NMO; MS 4A / CH2Cl2 / 1.5 h
4.1: NH2OH*HCl; aq. NaOH / ethanol / 2 h
5.1: 100 percent / NCS / dimethylformamide / 0 - 50 °C
6.1: Et3N / CH2Cl2 / 0 - 20 °C
6.2: chiral HPLC on Chiralpak AD column
With
sodium hydroxide; potassium dihydrogenphosphate; N-chloro-succinimide; lithium aluminium tetrahydride; N-methyl-2-indolinone; tetrapropylammonium perruthennate; hydroxylamine hydrochloride; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm020248u
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: NH2OH*HCl; aq. NaOH / ethanol / 2 h
2.1: 100 percent / NCS / dimethylformamide / 0 - 50 °C
3.1: Et3N / CH2Cl2 / 0 - 20 °C
3.2: chiral HPLC on Chiralpak AD column
With
sodium hydroxide; N-chloro-succinimide; hydroxylamine hydrochloride; triethylamine;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020248u
