4-(Piperidin-1-ium-4-YL)morpholin-4-ium

Base Information

• Chemical Name: 4-(Piperidin-1-ium-4-YL)morpholin-4-ium
• CAS No.: 436099-97-7
• Molecular Formula: C9H20N2O+2
• Molecular Weight: 284.279
• DSSTox Substance ID: DTXSID40963084
• Wikidata: Q82944894
• Mol file: 436099-97-7.mol

Synonyms:DTXSID40963084;AKOS015918409;4-(PIPERIDIN-1-IUM-4-YL)MORPHOLIN-4-IUM

Chemical Property of 4-(Piperidin-1-ium-4-YL)morpholin-4-ium

Chemical Property:

• Melting Point: 40-43 ºClit.)
• Boiling Point: 100-115 ºC0.15-0.20 mm Hg(lit.)
• Flash Point: >230 ºF
• PSA: 24.50000
• Density: g/cm³
• LogP: 0.33730
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 172.157563266
• Heavy Atom Count: 12
• Complexity: 129

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Piperidin-4-yl-morpholinetrifluoroacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C[NH2+]CCC1[NH+]2CCOCC2

Technology Process of 4-(Piperidin-1-ium-4-YL)morpholin-4-ium

There total 2 articles about 4-(Piperidin-1-ium-4-YL)morpholin-4-ium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trifluoroacetic acid (76-05-1) + 4-(piperidin-4-yl)morpholine (53617-35-9) → 4-piperidin-4-yl-morpholine bis-trifluoroacetate (436099-97-7)

Guidance literature:

In dichloromethane; at 20 ℃; for 1h;

Reference yield: 89.0%

tert-butyl 4-(morpholin-4-yl)piperidine-1-carboxylate (125541-20-0) + trifluoroacetic acid (76-05-1) → 4-piperidin-4-yl-morpholine bis-trifluoroacetate (436099-97-7)

Guidance literature:

In dichloromethane; at 20 ℃; for 1.5h;

Reference yield: 75.0%

4-piperidin-4-yl-morpholine bis-trifluoroacetate (436099-97-7) + 2-chlorophenylsulfonyl chloride (2905-23-9) → 4-{1-[(2-chlorophenyl)sulfonyl]piperidin-4-yl}morpholine hydrochloride

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

upstream raw materials:

trifluoroacetic acid

4-(piperidin-4-yl)morpholine

tert-butyl 4-(morpholin-4-yl)piperidine-1-carboxylate

Refernces

• 1、 -. "Diaminothiazoles". Page/Page column 15. . Retrieved 2008/06/13.