3-(4-Chlorophenyl)quinazoline-2,4(1H,3H)-dione

Base Information

• Chemical Name: 3-(4-Chlorophenyl)quinazoline-2,4(1H,3H)-dione
• CAS No.: 2400-95-5
• Molecular Formula: C14H9ClN2O2
• Molecular Weight: 272.691
• Hs Code.: 2933990090
• Mol file: 2400-95-5.mol

Synonyms:3-(4-chloro-phenyl)-2,4-quinazolinedione;3-(4-chlorophenyl)-1H,3H-quinazolin-2,4-dione;3-(4-chlorophenyl)-2,4(1H,3H)-quinazolinedione;3-(4-Chlordesyl)-rhodanin;4-Thiazolidinone,3-[1-(4-chlorophenyl)-2-phenylethyl]-2-thioxo;3-[1-(4-chloro-phenyl)-2-phenyl-ethyl]-2-thioxo-thiazolidin-4-one;3-(p-chlorophenyl)-2,4-(1H,3H)-quinazolinedione;3-(4-chloro-phenyl)-1H-quinazoline-2,4-dione;

Chemical Property of 3-(4-Chlorophenyl)quinazoline-2,4(1H,3H)-dione

Chemical Property:

• Melting Point: 268-271 °C
• PKA: 12.25±0.20(Predicted)
• PSA: 54.86000
• Density: 1.416±0.06 g/cm3(Predicted)
• LogP: 2.33240

Purity/Quality:

99% ^*data from raw suppliers

3-(4-Chlorophenyl)quinazoline-2,4(1H,3H)-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-Chlorophenyl)quinazoline-2,4(1H,3H)-dione

There total 23 articles about 3-(4-Chlorophenyl)quinazoline-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

isatoic anhydride (118-48-9) + diethyl (4-chlorophenyl)phosphoramidate (49802-15-5) → 3-(4-chlorophenyl)-1H,3H-quinazolin-2,4-dione (2400-95-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; benzene; at 80 ℃; for 5h;

DOI:10.1055/s-1982-29760

Reference yield: 95.0%

methyl 2-[3-(4-chlorophenyl)ureido]benzoate (19959-41-2) → 3-(4-chlorophenyl)-1H,3H-quinazolin-2,4-dione (2400-95-5)

Guidance literature:

With sodium hydroxide; In ethanol;

Reference yield: 90.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + 4-chloro-aniline (106-47-8) → 3-(4-chlorophenyl)-1H,3H-quinazolin-2,4-dione (2400-95-5)

Guidance literature:

With dihydrogen peroxide; sodium hydrogencarbonate; In methanol; water; at 20 ℃; for 8h; Green chemistry;

DOI:10.1002/cjoc.201700280

upstream raw materials:

isatoic anhydride

diethyl (4-chlorophenyl)phosphoramidate

methyl 2-[3-(4-chlorophenyl)ureido]benzoate

N-(4-Chloro-phenyl)-2-(3,3-dimethyl-ureido)-benzamide

Downstream raw materials:

3-(4-chlorophenyl)quinazoline-2,4(1H,3H)-dithione

1-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]-3-(4-chlorophenyl)quinazoline-2,4-dione

3-(4-chlorophenyl)-1-(4-chlorophenylsulfonyl)quinazoline-2,4(1H,3H)-dione

3-(4-chlorophenyl)-1-phenylsulfonylquinazoline-2,4(1H,3H)-dione