2-AMINO-5-(3,4-DIMETHOXYPHENYL)-1,3,4-THIADIAZOLE

Base Information

• Chemical Name: 2-AMINO-5-(3,4-DIMETHOXYPHENYL)-1,3,4-THIADIAZOLE
• CAS No.: 5427-87-2
• Molecular Formula: C10H11 N3 O2 S
• Molecular Weight: 237.282
• Hs Code.: 2934999090
• Mol file: 5427-87-2.mol

Synonyms:1,3,4-Thiadiazole,2-amino-5-(3,4-dimethoxyphenyl)- (8CI); NSC 13124

Chemical Property of 2-AMINO-5-(3,4-DIMETHOXYPHENYL)-1,3,4-THIADIAZOLE

Chemical Property:

• Vapor Pressure: 3.39E-07mmHg at 25°C
• Boiling Point: 418°C at 760 mmHg
• Flash Point: 206.6°C
• PSA: 98.50000
• Density: 1.311g/cm³
• LogP: 2.38570

Purity/Quality:

98%min ^*data from raw suppliers

5-(3,4-Dimethoxy-phenyl)-[1,3,4]thiadiazol-2-yl-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-(3,4-DIMETHOXYPHENYL)-1,3,4-THIADIAZOLE

There total 7 articles about 2-AMINO-5-(3,4-DIMETHOXYPHENYL)-1,3,4-THIADIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

thiosemicarbazide (79-19-6) + Veratric acid (93-07-2) → 2-amino-5-(3,4-dimethoxyphenyl)-1,3,4-thiadiazole (5427-87-2)

Guidance literature:

With trichlorophosphate; at 75 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2015.10.035

Reference yield: 79.0%

2-acetylamino-5-(3,4-dimethoxyphenyl)-1,3,4-thiadiazole (51680-06-9) → 2-amino-5-(3,4-dimethoxyphenyl)-1,3,4-thiadiazole (5427-87-2)

Guidance literature:

With sodium hydroxide; pH=12;

Reference yield: 44.0%

2-(3,4-dimethoxybenzylidene)hydrazine-1-carbothioamide (6292-77-9) → 2-amino-5-(3,4-dimethoxyphenyl)-1,3,4-thiadiazole (5427-87-2)

Guidance literature:

With iron(III) chloride hexahydrate; In ethanol; for 12h; Reflux;

DOI:10.3390/molecules24213988

upstream raw materials:

2-(3,4-dimethoxybenzylidene)hydrazine-1-carbothioamide

2-acetylamino-5-(3,4-dimethoxyphenyl)-1,3,4-thiadiazole

thiosemicarbazide

Veratric acid

Downstream raw materials:

2-(2,4-dioxo-1,3-thiazolidin-5-yl)-N-(5-(-3,4-dimethoxyphenyl)-1,3,4-thiadiazol-2-yl)acetamide

C₁₆H₁₄FN₅O₅S