1-(2,4,5-TRIMETHOXYPHENYL)-2-NITROETHENE

Base Information

• Chemical Name: 1-(2,4,5-TRIMETHOXYPHENYL)-2-NITROETHENE
• CAS No.: 24160-51-8
• Molecular Formula: C11H13NO5
• Molecular Weight: 239.22500
• Mol file: 24160-51-8.mol

Synonyms:

Chemical Property of 1-(2,4,5-TRIMETHOXYPHENYL)-2-NITROETHENE

Chemical Property:

• PSA: 73.51000
• LogP: 2.48300
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, DCM, Ethyl Acetate

Purity/Quality:

99% ^*data from raw suppliers

2,4,5-Trimethoxy-omega-nitrostyrene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4,5-Trimethoxy-ω-nitrostyrene is an analog of dopamine (D533780), a antihypotensive agent.

Technology Process of 1-(2,4,5-TRIMETHOXYPHENYL)-2-NITROETHENE

There total 3 articles about 1-(2,4,5-TRIMETHOXYPHENYL)-2-NITROETHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Nitroethane (79-24-3) + asaronic acid (490-64-2) → 1-(2,4,5-trimethoxyphenyl)-2-nitroethene (86255-45-0,24160-51-8)

Guidance literature:

With palladium(II) trifluoroacetate; dimethyl sulfoxide; silver carbonate; Trimethylacetic acid; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c0cc01029d

Reference yield: 48.0%

nitromethane (75-52-5) + asaraldehyde (4460-86-0,14374-62-0) → 1-(2,4,5-trimethoxyphenyl)-2-nitroethene (86255-45-0,24160-51-8)

Guidance literature:

With cyclohexylamine; at 120 ℃; Microwave irradiation;

DOI:10.2174/1573406413666171002123907

Reference yield:

→ 1-(2,4,5-trimethoxyphenyl)-2-nitroethene (86255-45-0,24160-51-8)

Guidance literature:

1, 1,2,4-Trimethoxybenzol;

DOI:10.1021/jo00430a024

upstream raw materials:

nitromethane

asaraldehyde

Nitroethane

asaronic acid

Downstream raw materials:

1-(2,4,5-trimethoxyphenyl)-2-aminoethane

Refernces

• 1、 Zhang, Min,Zhou, Jun,Kan, Jian,Wang, Min,Su, Weiping,Hong, Maochun. "Pd-catalyzed cross-coupling of carboxylic acids with nitroethane via combination of decarboxylation and dehydrogenation". supporting information; experimental part. p. 5455 - 5457. Retrieved 2010/10/04.